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CARBAZEPIN TABLETS

 

 
 

SIZE:

200mg

 

GENERIC NAME:

CARBAMAZEPINE

 

MANUFACTURER:

الشرق

 

UNIT:

 

ADMINISTRATION ROUTE:

 

FDA PREGNANCY GROUP:

C

 

INDICATIONS:

Seizures, mixed pattern

Neuralgia, glossopharyngeal

Neuralgia, trigeminal

Seizures, complex partial

Seizures, generalized tonic- clonic

 

SIDE EFFECTS:

Aching joints or muscles, or leg cramps

Adenopathy or lymphadenopathy

agranulocytosis

Allergic reaction

alopecia

anorexia

atrioventricular (AV) heart block

behavioral changes

blood dyscrasias, including aplastic anemia

bone marrow depression

bradycardia

cardiovascular effects, including arrhythmias

Clumsiness or unsteadiness

CNS toxicity

CNS toxicity , including blurred or double vision

confusion

congestive heart failure

constipation

diaphoresis

diarrhea

diarrhea, severe

dizziness, mild , or lightheadedness

drowsiness, mild

dryness of mouth

edema

eosinophilia

glossitis or stomatitis

headache

hypersensitivity hepatitis

hypertension, increased

hypocalcemia

hyponatremia , dilutional, or water intoxication (SIADH)

hypotension

increased sensitivity of skin to sunlight

leukopenia

nausea or vomiting, mild

nystagmus

pancytopenia

paresthesias or peripheral neuritis

porphyria, acute intermittent

pulmonary hypersensitivity

renal toxicity, renal failure, acute, or water intoxication (SIADH)

sexual problems in males

Stevens-Johnson syndrome

stomach pain or discomfort

syncope

systemic lupus erythematosus (SLE)-like syndrome

thrombocytopenia

thrombophlebitis

toxic epidermal necrolysis

unusual tiredness or weakness

 

ABSOLUTE CONTRAINDICATIONS :

 

RELATIVE CONTRAINDICATIONS :

Alcoholism, active

Behavioral disorders

Cardiac damage, includingngestive heart disease

Coronary artery disease

Diabetes mellitus

Glaucoma

Hematologic reactions, adverse, to other medications

Hepatic function impairment

Hyponatremia, dilutional, caused by syndrome of inappropriate antidiuretic hormone secretion

Increased intraocular pressure

Renal function impairment

Sensitivity to carbamazepine or to tricyclic antidepressants

Urinary retention

 

ADULT DOSE:

Anticonvulsant-Initial: Oral, 200 mg two times a day on the first day, the dosage being increased by up to 200 mg a day at weekly intervals until the best response is obtained. Some clinicians recommend initiating therapy at 100 mg a day and increasing to full therapeutic dosage slowly at weekly intervals to avoid side effects and potential noncompliance. Maintenance: Oral, adjusted to the minimum effective dosage, usually 600 mg to 1.6 grams a day. Antineuralgic-Initial: Oral, 100 mg two times a day on the first day, the dosage being increased by up to 200 mg a day, using increments of 100 mg every twelve hours only as needed until pain is relieved. Maintenance: Oral, 200 mg to 1.2 grams a day (average 400 to 800 mg a day) in divided doses. [Antidiuretic] -Oral, 300 to 600 mg a day if used as sole therapy; or 200 to 400 mg a day if used concurrently with other antidiuretic agents. [Antimanic] or [Antipsychotic] -Oral, initially 200 to 400 mg a day in divided doses, the dosage being gradually increased at weekly intervals up to a maximum of 1.6 grams a day as needed and tolerated according to clinical response. Note: Whenever possible, total daily dosage should be given in 3 or 4 divided doses.

 

MAXIMUM ADULT DOSE:

Anticonvulsant-Patients 12 to 15 years of age- Dosage should generally not exceed 1 gram a day. Patients 15 years of age and over- Dosage should generally not exceed 1.2 grams a day. In rare instances, doses of up to 1.6 grams a day have been used in adults. Antineuralgic-Dosage should not exceed 1.2 grams a day.

 

PEDIATRIC DOSE:

Anticonvulsant-Children up to 6 years of age - Initial-Oral, 10 to 20 mg per kg of body weight a day in two or three divided doses, the dosage being increased by up to 100 mg a day at weekly intervals as needed and tolerated. Maintenance-Oral, adjusted to the minimum effective dosage, usually 250 to 350 mg a day, and generally not exceeding 400 mg or 35 mg per kg of body weight a day. Children 6 to 12 years of age- Initial-Oral, 100 mg two times a day on the first day, the dosage being increased by 100 mg a day at weekly intervals until the best response is obtained. Maintenance-Oral, adjusted to the minimum effective dosage, usually 400 to 800 mg a day. Note: Dosage generally should not exceed 1 gram a day. Whenever possible, total daily dosage should be given in 3 or 4 divided doses. 

 

MAXIMUM PEDIATRIC DOSE:

 

ELDERLY DOSE:

 

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