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Acetaminophen; Dichloralphenazone; Isometheptene Mucate  (0064)
[ ah-seet'-ah-min-oh-fen; dye-klor-al-fen'-a-zone; i-so-meh-thep'-tene ]
Ingredients: Acetaminophen; Dichloralphenazone; Isometheptene Mucate
Indications: Headache, tension; Headache, vascular
Pregnancy Category: (none)
FDA Approved: pre- 1938
Classes: Adrenergic agonists; Analgesics, non- narcotic; Sedatives/ hypnotics
Brand Names: Amidrine - US ; Aperon - Korea ; Daccorin - Korea ; Duradrin - US ; Epidrin - US ; I.D.A. - US ; Iso-Acetazone - US ; Midrin - US ; Migaphen - Korea ; Migquin - US ; Migrapap - US ; Migratine - US ; Migrazone - US ; Mydran - Korea ; Mydrin - Korea ; Va-zone - US ;
DEA schedules: (none)
Cost of therapy: $7.54 ( Headache ; Generic Capsules (Migrapap) ; 325 mg; 100 mg; 65 mg ; 6 capsule(s)/day ; 7 day supply )
$24.78 ( Headache ; Midrin ; 325 mg; 100 mg; 65 mg ; 6 capsule(s)/day ; 7 day supply )

DESCRIPTION
  Each red Midrin capsule with pink band contains isometheptene mucate 65 mg, dichloralphenazone 100 mg, and acetaminophen 325 mg.
Isometheptene mucate is a white, crystalline powder having a characteristic aromatic odor and bitter taste. It is an unsaturated aliphatic amine with sympathomimetic properties.
Dichloralphenazone is a white, microcrystalline powder, with slight odor and tastes saline at first, becoming acrid. It is a mild sedative.
Acetaminophen, a non- salicylate, occurs as a white, odorless, crystalline powder possessing a slightly bitter taste.
Midrin capsules contain FD&C yellow no. 6 as a color additive.

CLINICAL PHARMACOLOGY
  Isometheptene mucate, a sympathomimetic amine, acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches. Dichloralphenazone, a mild sedative, reduces the patient's emotional reaction to the pain of both vascular and tension headaches. Acetaminophen raises the threshold to painful stimuli, thus exerting an analgesic effect against all types of headaches.

INDICATIONS AND USAGE
  For relief of tension and vascular headaches.*
*Based on a review of this drug (isometheptene mucate) by the National Academy of Sciences—National Research Council and/ or other information, FDA has classified the other indication as "possibly" effective in the treatment of migraine headache. Final classification of the less- than- effective indication requires further investigation.

CONTRAINDICATIONS
  This drug is contraindicated in glaucoma and/ or severe cases of renal disease, hypertension, organic heart disease, hepatic disease and in those patients who are on monoamine- oxidase (MAO) inhibitor therapy.

PRECAUTIONS
  Caution should be observed in hypertension, peripheral vascular disease and after recent cardiovascular attacks.

ADVERSE REACTIONS
  Transient dizziness and skin rash may appear in hypersensitive patients. This can usually be eliminated by reducing the dose.

DOSAGE AND ADMINISTRATION
 
For Relief of Migraine Headache: The usual adult dosage is 2 capsules at once, followed by 1 capsule every hour until relieved, up to 5 capsules within a 12 hour period.

For Relief of Tension Headache: The usual adult dosage is 1 or 2 capsules every four hours up to 8 capsules a day.

Storage: Store at controlled room temperature 15- 30°C (59- 86°F) in a dry place.

PRODUCT IDENTIFICATION
  Acetaminophen; Dichloralphenazone; Isometheptene Mucate , capsule , 325 mg-100 mg-65 mg [ Carnrick Laboratories Inc ]
Acetaminophen; Dichloralphenazone; Isometheptene Mucate , capsule , 325 mg-100 mg-65 mg [ Barr Laboratories Inc ]
Acetaminophen; Dichloralphenazone; Isometheptene Mucate , capsule , 325 mg-100 mg-65 mg [ Barr Laboratories Inc ]
Acetaminophen; Dichloralphenazone; Isometheptene Mucate , capsule , 325 mg-100 mg-65 mg [ Jerome Stevens Pharmaceuticals Inc ]
Acetaminophen; Dichloralphenazone; Isometheptene Mucate , capsule , 325 mg-100 mg-65 mg [ Physicians Total Care ]

PATIENT DRUG CONSULT HANDOUT
  Acetaminophen; Dichloralphenazone; Isometheptene Mucate (oral)

PRODUCT LISTING - EQUIVALENTS NOT AVAILABLE
 
capsule - oral - 325 mg- 100 mg- 65 mg -
10.0 $3.89 Amidrine
Southwood Pharmaceuticals Inc 		58016028810
10.0 $5.50 Iso- Acetazone
Pharmaceutical Corporation of America 		51655045153
10.0 $9.31 Midrin
Prescript Pharmaceuticals 		00247014510
12.0 $4.66 GENERIC
Southwood Pharmaceuticals Inc 		58016028812
14.0 $5.44 GENERIC
Southwood Pharmaceuticals Inc 		58016032214
15.0 $5.83 GENERIC
Southwood Pharmaceuticals Inc 		58016028815
15.0 $8.42 Midrin
Allscripts Healthcare Solutions 		54569034303
15.0 $12.28 Midrin
Prescript Pharmaceuticals 		00247014515
18.0 $6.99 GENERIC
Southwood Pharmaceuticals Inc 		58016028818
20.0 $7.77 GENERIC
Southwood Pharmaceuticals Inc 		58016028820
20.0 $7.79 Va- zone
PD- RX Pharmaceuticals 		55289038320
20.0 $8.57 Migquin
Allscripts Healthcare Solutions 		54569466501
20.0 $11.22 Midrin
Allscripts Healthcare Solutions 		54569034302
20.0 $12.56 GENERIC
Pharma Pac 		52959044720
20.0 $15.27 Midrin
Prescript Pharmaceuticals 		00247014520
21.0 $8.16 GENERIC
Southwood Pharmaceuticals Inc 		58016028821
24.0 $9.32 GENERIC
Southwood Pharmaceuticals Inc 		58016028824
25.0 $9.71 GENERIC
Southwood Pharmaceuticals Inc 		58016028825
25.0 $18.25 Midrin
Prescript Pharmaceuticals 		00247014525
28.0 $10.88 GENERIC
Southwood Pharmaceuticals Inc 		58016028828
28.0 $11.51 Iso- Acetazone
Pharmaceutical Corporation of America 		51655045129
30.0 $9.39 GENERIC
Physicians Total Care 		54868151403
30.0 $11.85 Migquin
Allscripts Healthcare Solutions 		54569466502
30.0 $14.62 GENERIC
Southwood Pharmaceuticals Inc 		58016028830
30.0 $16.83 Midrin
Allscripts Healthcare Solutions 		54569034300
30.0 $17.59 GENERIC
Pharma Pac 		52959044730
40.0 $15.54 GENERIC
Southwood Pharmaceuticals Inc 		58016028840
50.0 $14.55 GENERIC
Physicians Total Care 		54868151404
50.0 $19.75 GENERIC
Interpharm Inc 		53746014150
50.0 $21.25 GENERIC
Southwood Pharmaceuticals Inc 		58016028850
50.0 $21.45 Migquin
Allscripts Healthcare Solutions 		54569466500
50.0 $28.05 Midrin
Women First Healthcare 		64248012005
50.0 $28.05 Midrin
Allscripts Healthcare Solutions 		54569034301
50.0 $28.71 Midrin
Physicians Total Care 		54868143501
50.0 $28.88 GENERIC
Pharma Pac 		52959044750
50.0 $33.13 Midrin
Prescript Pharmaceuticals 		00247014550
60.0 $10.07 Va- zone
PD- RX Pharmaceuticals 		55289038360
60.0 $17.12 GENERIC
Physicians Total Care 		54868151401
60.0 $23.31 GENERIC
Southwood Pharmaceuticals Inc 		58016028860
90.0 $13.40 Va- zone
PD- RX Pharmaceuticals 		55289038390
100.0 $17.95 Migrapap
Mikart Inc 		46672025310
100.0 $19.00 Migratine
Major Pharmaceuticals Inc 		00904158860
100.0 $19.71 Migquin
Vintage Pharmaceuticals Inc 		00254427028
100.0 $22.68 Va- zone
PD- RX Pharmaceuticals 		55289035517
100.0 $26.60 GENERIC
Physicians Total Care 		54868151400
100.0 $26.81 Migrapap
Par Pharmaceutical Inc 		49884081201
100.0 $38.46 I.D.A.
IVAX Corporation 		00182123401
100.0 $38.85 GENERIC
Southwood Pharmaceuticals Inc 		58016028800
100.0 $39.55 Migratine
Major Pharmaceuticals Inc 		00904762260
100.0 $39.55 Migratine
Major Pharmaceuticals Inc 		00904549160
100.0 $40.00 GENERIC
Interpharm Inc 		53746014101
100.0 $40.75 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company 		00677112501
100.0 $42.50 Epidrin
Excellium Pharmaceuticals Inc 		64125010101
100.0 $42.90 Duradrin
Barr Laboratories Inc 		00555036402
100.0 $42.90 Duradrin
Barr Laboratories Inc 		51285036402
100.0 $42.90 Migquin
Qualitest Pharmaceuticals Inc 		00603466421
100.0 $43.85 Amidrine
Amide Pharmaceutical Inc 		52152003902
100.0 $43.86 Migrazone
Breckenridge Pharmaceutical Inc 		51991039501
100.0 $43.87 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company 		00677173901
100.0 $53.63 Midrin
Women First Healthcare 		64248012010
100.0 $55.65 Midrin
Physicians Total Care 		54868143502
100.0 $62.92 Midrin
Prescript Pharmaceuticals 		00247014500
250.0 $19.08 Migquin
Qualitest Pharmaceuticals Inc 		00603466424
250.0 $31.75 Migrapap
Mikart Inc 		46672025325
250.0 $37.75 Migquin
Vintage Pharmaceuticals Inc 		00254427033
250.0 $46.45 Migratine
Major Pharmaceuticals Inc 		00904158870
250.0 $46.45 Migratine
Major Pharmaceuticals Inc 		00904762270
250.0 $48.95 Migrapap
Par Pharmaceutical Inc 		49884081204
250.0 $65.14 Migrazone
Breckenridge Pharmaceutical Inc 		51991039502
250.0 $75.95 Amidrine
Amide Pharmaceutical Inc 		52152003903
250.0 $78.75 GENERIC
Interpharm Inc 		53746014102
250.0 $79.15 Migratine
Major Pharmaceuticals Inc 		00904549170
250.0 $81.95 Epidrin
Excellium Pharmaceuticals Inc 		64125010102
500.0 $79.55 Migrazone
Breckenridge Pharmaceutical Inc 		51991039505
500.0 $105.00 GENERIC
Interpharm Inc 		53746014105
1000.0 $295.00 Amidrine
Amide Pharmaceutical Inc 		52152003905

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