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Acetaminophen; Codeine Phosphate  (0051)
[ a-seat-a-min'-oh-fen; koe'-deen foss'-fate ]
Ingredients: Acetaminophen; Codeine Phosphate
Indications: Pain, moderate to severe
Pregnancy Category: C
FDA Approved: 1981- 12- 01
Classes: Analgesics, narcotic
Brand Names: Algesidal - France ; Algimide - Colombia ; Algimide F - Colombia ; Capital with Codeine Suspension - US ; Chemists Own Dolased Day Pain Relief - Australia ; Claradol Codeine - France ; Co-Cadamol - Singapore ; Codabrol - Israel ; Cod-Acamol Forte - Israel ; Codalgin - AUSTRALIA ; Codapane - AUSTRALIA ; Codeidol - Colombia ; Codeidol F - Colombia ; Codeipar - Chile ; Codicet - Thailand ; Codilprane Enfant - France ; Codipar - England, Ireland ; Codisal Forte - Israel ; Coditam - Indonesia ; Codoliprane - France ; Codoliprane Enfant - France ; Codral Pain Relief - AUSTRALIA ; Dafalgan Codeine - France ; Dolorol Forte - South-africa ; Dymadon Co - AUSTRALIA ; Dymadon Forte - AUSTRALIA ; Efferalgan Codeine - Israel, Paraguay ; Empracet-30 - Canada ; Empracet-60 - Canada ; EZ III - US ; Febricod - Australia ; Liquigesic Co - AUSTRALIA ; Maxadol - South-africa ; Nasa w/codeine - Thailand ; Paceco - Malaysia, Singapore ; Panadeine - Czech-republic, Hong-kong, Hungary, Malaysia ; Panadeine Co - MIDDLEEAST ; Panadeine Forte - AUSTRALIA ; Panadiene - AUSTRALIA, CARIBBEAN; Czech-republic, Hong-kong, Hungary, Japan, Malaysia, New-zealand ; Panado-Co Caplets - South-africa ; Panamax - AUSTRALIA ; Paracod - Israel ; Paracodol - South-africa ; Paradine - Malaysia ; Parcono - Thailand ; Parcoten - Hong-kong ; Perdolan Codeine - Belgium ; Prodeine-15 - Australia ; Prodeine Forte - Australia ; Rockamol Plus - Israel ; Solpadeine - MIDDLEEAST(Except Israel ) ; Solpadol - England, Ireland ; TWC 30 - India ; Tylenol W/Codeine No. 4 - Canada ; Tylenol with Codeine - US ; Tylenol with Codeine #2 - US ; Tylenol with Codeine #3 - US ; Tylenol with Codeine #4 - US ; Tylex CD - Costa-rica, Dominican-republic, El-salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama ; Winadol Forte - Colombia ; Zapain - England, Ireland ;
DEA schedules: Schedule III; Schedule V
Cost of therapy: $9.75 ( Moderate-Severe Pain ; Generic Elixir (Mikart) ; 120 mg-12 mg per 5 ml ; 75 ml/day ; 5 day supply )
$10.84 ( Moderate-Severe Pain ; Generic Tablets (Qualitest) ; 300 mg; 30 mg ; 6 tablets/day ; 5 day supply )
$17.04 ( Moderate-Severe Pain ; Tylenol with Codeine #3 ; 300 mg; 30 mg ; 6 tablets/day ; 5 day supply )
$49.23 ( Moderate-Severe Pain ; Capital with Codeine Suspension ; 120 mg-12 mg per 5 ml ; 75 ml/day ; 5 day supply )

DESCRIPTION

  Acetaminophen, 4′- hydroxyacetanilide, is a nonopiate, non- salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. It has the following structural formula:
C8 H9 NO2 , with a molecular meight of 151.16
Codeine is an alkaloid, obtained from opium or prepared from morphine by methylation. Codeine phosphate occurs as fine, white, needle- shaped crystals, or white, crystalline powder. It is affected by light. Its chemical name is: 7, 8- didehydro- 4, 5α- epoxy- 3- methoxy- 17- methylmorphinan- 6α- ol phosphate (1:1) (salt) hemihydrate. It has the following molecular formula: C18 H21 NO3 ·H3 PO4 ·½H2 O with a molecular weight of 406.37

Tablets and Elixir

  Each Tylenol With Codeine Tablet Contains:
No. 2 Codeine Phosphate: 15 mg ( Warning: May be habit forming.)
Acetaminophen: 300 mg

No. 3 Codeine Phosphate: 30 mg ( Warning: May be habit forming.)
Acetaminophen: 300 mg

No. 4 Codeine Phosphate: 60 mg ( Warning: May be habit forming.)
Acetaminophen: 300 mg

Each 5 ml of Tylenol With Codeine Elixir Contains:
Codeine Phosphate: 12 mg ( Warning: May be habit forming.)
Acetaminophen: 120 mg
Alcohol 7%


Tylenol Inactive Ingredients: Tablets: Powdered cellulose, magnesium stearate, sodium metabisulfite (see WARNINGS ), pregelatinized starch, starch (corn); Elixir: Alcohol, citric acid, propylene glycol, sodium benzoate, saccharin sodium, sucrose, natural and artificial flavors, FD&C yellow no. 6.

Capsules

 

Phenaphen w/Codeine No. 2 Capsule

  Each Phenaphen w/ Codeine No. 2 Capsule Contains:
Acetaminophen: 325 mg
Codeine Phosphate: 15 mg ( Warning: May be habit forming.)


Inactive Ingredients: Corn starch, FD&C yellow no. 10, edible ink, FD&C blue no. 1, FD&C red no. 40, FD&C yellow no. 6, gelatin, magnesium stearate, sodium starch glycolate, stearic acid.

Phenaphen w/Codeine No. 3 Capsule

  Each Phenaphen w/ Codeine No. 3 Capsule Contains:
Acetaminophen: 325 mg
Codeine Phosphate: 30 mg ( Warning: May be habit forming.)


Inactive Ingredients: FD&C yellow no. 10, edible ink, FD&C blue no. 1, (FD&C green no. 3 and red no. 40), FD&C yellow no. 6, gelatin, magnesium stearate, sodium starch glycolate, stearic acid.

Phenaphen w/Codeine No. 4 Capsule

  Each Phenaphen w/ Codeine No. 4 Capsule Contains:
Acetaminophen: 325 mg
Codeine Phosphate: 60 mg ( Warning: May be habit forming.)


Inactive Ingredients: Corn starch, FD&C yellow no. 10, edible ink, FD&C green no. 3 or blue no. 1, FD&C yellow no. 6, gelatin, lactose, magnesium stearate, sodium starch glycolate stearic acid.

CLINICAL PHARMACOLOGY

  Acetaminophen and codeine phosphate tablets, oral solution, and capsules, combine the analgesic effects of a centrally acting analgesic, codeine, with a peripherally acting analgesic, acetaminophen. Both ingrediants are well absorbed orally. The plasma elimination half- life ranges from 1- 4 hours for acetaminophen, and from 2.5 to 3 hours for codeine.

Pharmacokinetics

  The behavior of the individual components is described below:
Codeine: Codeine retains at least one- half of its analgesic activity when administered orally. A reduced first- pass metabolism of codeine by the liver accounts for the greater oral efficacy of codeine when compared to most other morphine- like narcotics. Following absorption, codeine is metabolized by the liver and metabolic products are excreted in the urine. Approximately 10% of the administered codeine is demethylated to morphine, which may account for its analgesic activity.
Acetaminophen: Acetaminophen is distributed throughout most fluids of the body, and is metabolized primarily in the liver. Little unchanged drug is excreted in the urine, but most metabolic products appear in the urine within 24 hours.

INDICATIONS AND USAGE

  Acetaminophen and codeine phosphate tablets and capsules are indicated for the relief of mild to moderately severe pain.
Acetaminophen and codeine phosphate oral solution is indicated for the relief of mild to moderate pain.

CONTRAINDICATIONS

  Acetaminophen and codeine phosphate tablets, oral solution, or capsules, should not be administered to patients who have previously exhibited hypersensitivity to any component.

WARNINGS

  Acetaminophen and codeine phosphate tablets contain sodium metabisulfite, a sulfite that may cause allergic- type reactions including anaphylactic symptoms and life- threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

PRECAUTIONS

 

General

 

Head Injury and Increased Intracranial Pressure

  The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre- existing increase in intracranial pressure. Furthermore, narcotics produce adverse reactions which may obscure the clinical course of patients with head injuries.

Acute Abdominal Conditions

  The administration of this product or other narcotics may obscure the diagnosis or clinical course of patients with acute abdominal conditions.

Special Risk Patients

  This drug should be given with caution to certain patients such as the elderly or debilitated, and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, and prostatic hypertrophy or urethral stricture.

Information for the Patient

  Codeine may impair the mental and/ or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. The patient using this drug should be cautioned accordingly.
The patient should understand the single- dose and 24 hour dose limits, and the time interval between doses.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

  No long- term studies in animals have been performed with acetaminophen or codeine to determine carcinogenic potential or effects on fertility.
Acetaminophen and codeine have been found to have no mutagenic potential using the Ames Salmonella- Microsomal Activation test, the Basc test on Drosophila germ cells, and the Micronucleus test on mouse bone marrow.

Pregnancy Category C

 

Teratogenic Effects

 

Codeine

  A study in rats and rabbits reported no teratogenic effect of codeine administered during the period of organogenesis in doses ranging from 5 to 120 mg/ kg. In the rat, doses at the 120 mg/ kg level, in the toxic range for the adult animal, were associated with an increase in embryo resorption at the time of implantation. In another study a single 100 mg/ kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification in the offspring.
There are no studies in humans, and the significance of these findings to humans, if any, is not known.
Acetaminophen and codeine phosphate tablets, oral solution, or capsules, should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects

  Dependence has been reported in newborns whose mothers took opiates regularly during pregnancy. Withdrawal signs include irritability, excessive crying, tremors, hyperreflexia, fever, vomiting, and diarrhea. These signs usually appear during the first few days of life.

Labor and Delivery

  Narcotic analgesics cross the placental barrier. The closer to delivery and the larger the dose used, the greater the possibility of respiratory depression in the newborn. Narcotic analgesics should be avoided during labor if delivery of a premature infant is anticipated. If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression. Resuscitation may be required (see OVERDOSAGE ). The effect of codeine, if any, on the later growth, development, and functional maturation of the child is unknown.

Nursing Mothers

  Some studies, but not others, have reported detectable amounts of codeine in breast milk. The levels are probably not clinically significant after usual therapeutic dosage. The possibility of clinically important amounts being excreted in breast milk in individuals abusing codeine should be considered.

Pediatric Use

  Safe dosage of acetaminophen and codeine phosphate oral solution USP has not been established in children below the age of three years.

DRUG INTERACTIONS

  Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with this drug may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.
The concurrent use of anticholinergics with codeine may produce paralytic ileus.

ADVERSE REACTIONS

  The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, shortness of breath, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in non- ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include allergic reactions, euphoria, dysphoria, constipation, abdominal pain, and pruritus.
At higher doses, codeine has most of the disadvantages of morphine including respiratory depression.

DRUG ABUSE AND DEPENDENCE

  Acetaminophen and codeine phosphate tablets and capsules are a Schedule III controlled substance.
Acetaminophen with codeine phosphate oral solution USP is a Schedule V controlled substance.
Codeine can produce drug dependence of the morphine type and, therefore, has the potential for being abused. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of this drug, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic- containing medications.

OVERDOSAGE

 

Acetaminophen

 

Signs and Symptoms

  In acute acetaminophen overdosage, dose- dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur.
In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams and fatalities with less than 15 grams. Importantly, young children seem to be more resistant than adults to the hepatotoxic effect of an acetaminophen overdose. Despite this, the measures outlined below should be initiated in any adult or child suspected of having ingested an acetaminophen overdose.

Early symptoms following a potentially hepatotoxic overdose may include: Nausea, vomiting, diaphoresis, and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48- 72 hours post- ingestion.

Treatment

  The stomach should be emptied promptly by lavage or by induction of emesis with syrup of ipecac. Patients' estimates of the quantity of a drug ingested are notoriously unreliable. Therefore, if an acetaminophen overdose is suspected, a serum acetaminophen assay should be obtained as early as possible, but no sooner than four hours following ingestion. Liver function studies should be obtained initially and repeated at 24 hour intervals.
The antidote, N- acetylcysteine, should be administered as early as possible, preferably within 16 hours of the overdose ingestion for optimal results, but in any case, within 24 hours. Following recovery, there are no residual, structural or functional hepatic abnormalities.

Codeine

 

Signs and Symptoms

  Serious overdose with codeine is characterized by respiratory depression (a decrease in respiratory rate and/ or tidal volume, Cheyne- Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest, and death may occur. Toxicity from codeine poisoning includes the opiod triad of: pinpoint pupils, depression of respiration, and loss of consciousness. Convulsions may occur.

Treatment

  Primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and the institution of assisted or controlled ventilation. In severe cases of intoxication, peritoneal dialysis, or preferably hemodialysis may be considered. If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. The narcotic antagonist naloxone is a specific antidote against respiratory depression which may result from overdosage or unusual sensitivity to narcotics, including codeine. Therefore, an appropriate dose of naloxone HCl should be administered (see DOSAGE AND ADMINISTRATION in the naloxone HCl prescribing information), preferably by the intravenous route, and simultaneously with efforts at respiratory resuscitation. Since the duration of action of codeine may exceed that of the antagonist, the patient should be kept under continued surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.
An antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated.
Gastric emptying may be useful in removing unabsorbed drug.

DOSAGE AND ADMINISTRATION

 

Tablets and Capsules

  Dosage should be adjusted according to severity of pain and response of the patient.
It should be kept in mind, however, that tolerance to codeine can develop with continued use and that the incidence of untoward effects is dose related. Adult doses of codeine higher than 60 mg fail to give commensurate relief of pain but merely prolong analgesia and are associated with an appreciably increased incidence of undesirable side effects. Equivalently high doses in children would have similar effects.
The usual adult dosage is shown in TABLE 1 .
TABLE 1    Usual Adult Dosage
  Single Doses (Range) Maximum 24 Hour Dose
Codeine Phosphate 15- 60 mg 360 mg
Acetaminophen 300- 1000 mg 4000 mg

Doses may be repeated up to every 4 hours.
The prescriber must determine the number of tablets or capsules per dose and the maximum number of tablets or capsules per 24 hours, based upon the dosage guidance in TABLE 1 . This information should be conveyed in the prescription.
For children, the dose of codeine phosphate is 0.5 mg/ kg.

Elixir

  Acetaminophen and codeine phosphate oral solution contains 120 mg of acetaminophen and 12 mg of codeine phosphate/ 5 ml and is given orally.
The usual doses are:

Children: 7- 12 Years: 10 ml (2 teaspoonfuls) 3 or 4 times daily. 3- 6 Years: 5 ml (1 teaspoonful) 3 or 4 times daily. Under 3 Years: Safe dosage has not been established.

Adults: 15 ml (1 tablespoonful) every 4 hours as needed.

HOW SUPPLIED

 

Tylenol With Codeine Tablets

  Round, white, imprinted "McNEIL", "TYLENOL CODEINE" and either "2", "3", "4".

Storage: Store tablets ar controlled room temperature (15- 30°C, 59- 86°F).
Dispense in tight, light- resistant container as defined in the official compendium.

Tylenol With Codeine Elixir

  Tylenol with codeine elixir contains 120 mg acetaminophen and 12 mg codeine phosphate/ 5ml.

Storage: Store elixir at controlled room temperature (15- 30°C, 59- 86°F). Protect from light. Do not refrigerate. Do not freeze.
Dispense in tight, light- resistant container as defined in the official compendium.

Phenaphen With Codeine Capsules

 
No. 2: Black and yellow capsules containing 325 mg acetaminophen and 15 mg codeine phosphate.
No. 3: Black and green capsules containing 325 mg acetaminophen and 30 mg codeine phosphate.
No. 4: Green and white capsules containing 325 mg acetaminophen and 60 mg codeine phosphate.


Storage: Store capsules at controlled room temperature (15- 30°C, 59- 86°F).
Dispense in tight, light- resistant container.

PRODUCT IDENTIFICATION

  Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Teva Pharmaceuticals USA ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Qualitest Pharmaceuticals Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Major Pharmaceuticals Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ UDL Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-60 mg [ Teva Pharmaceuticals USA ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-60 mg [ Qualitest Pharmaceuticals Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-60 mg [ Sandoz Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-60 mg [ UDL Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-15 mg [ Teva Pharmaceuticals USA ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-15 mg [ Qualitest Pharmaceuticals Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-15 mg [ Quality Care Products/Lake Erie Medical ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-15 mg [ Barr Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Barr Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Barr Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-60 mg [ Barr Laboratories Inc ]
Acetaminophen; Codeine Phosphate , tablet , 300 mg-30 mg [ Janssen Pharmaceuticals ]

PATIENT DRUG CONSULT HANDOUT

  Acetaminophen; Codeine Phosphate (oral)

PRODUCT LISTING - RATED THERAPEUTICALLY EQUIVALENT

 
liquid - oral - 120 mg- 12 mg/ 5 ml -
5.0 ml x 100.0 $55.00 GENERIC
Roxane Laboratories Inc
00054801304
5.0 ml x 100.0 $58.00 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050405
10.0 ml x 100.0 $35.65 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050410
12.0 ml x 100.0 $57.00 GENERIC
Roxane Laboratories Inc
00054800204
12.5 ml x 100.0 $60.00 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050412
15.0 ml x 100.0 $58.00 GENERIC
Roxane Laboratories Inc
00054801704
15.0 ml x 100.0 $61.00 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050415
120.0 ml $2.50 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050404
120.0 ml $3.48 GENERIC
Alpharma USPD
00472141904
120.0 ml $7.30 GENERIC
Morton Grove Pharmaceuticals Inc
60432024504
473.0 ml $63.82 Tylenol with Codeine
Janssen Pharmaceuticals
00045050816
480.0 ml $12.95 GENERIC
Sandoz Inc
00781605216
480.0 ml $12.96 GENERIC
Watson Pharmaceuticals
00364720716
480.0 ml $13.24 GENERIC
Major Pharmaceuticals Inc
00904017316
480.0 ml $18.55 GENERIC
IVAX Corporation
00182107840
480.0 ml $18.55 GENERIC
Alpharma USPD
00472141916
480.0 ml $19.82 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company
00677099633
480.0 ml $19.85 GENERIC
Qualitest Pharmaceuticals Inc
00603102058
480.0 ml $19.85 GENERIC
Pharmaceutical Assoc Inc Div Beach Products
00121050416
480.0 ml $19.85 GENERIC
Morton Grove Pharmaceuticals Inc
60432024516
500.0 ml $20.77 GENERIC
Roxane Laboratories Inc
00054300563
3840.0 ml $84.48 GENERIC
Major Pharmaceuticals Inc
00904777528
3840.0 ml $84.48 GENERIC
Major Pharmaceuticals Inc
00904017328
3840.0 ml $111.28 GENERIC
Alpharma USPD
00472141928
suspension - oral - 120 mg- 12 mg/ 5 ml -
480.0 ml $31.49 Capital with Codeine Suspension
Carnrick Laboratories Inc
00086004616
480.0 ml $57.81 Capital with Codeine Suspension
Amarin Pharmaceuticals Inc
65234004616
tablet - oral - 300 mg- 15 mg -
15.0's $2.92 GENERIC
PD- RX Pharmaceuticals
55289044915
100.0's $7.85 GENERIC
Vintage Pharmaceuticals Inc
00254206328
100.0's $8.20 GENERIC
IVAX Corporation
00182126801
100.0's $12.61 GENERIC
Major Pharmaceuticals Inc
00904057161
100.0's $26.92 GENERIC
Major Pharmaceuticals Inc
00904057160
100.0's $30.24 GENERIC
Mallinckrodt Medical Inc
00406048301
100.0's $30.44 GENERIC
Qualitest Pharmaceuticals Inc
00603233721
100.0's $30.44 GENERIC
Teva Pharmaceuticals USA
00093005001
100.0's $30.44 GENERIC
Watson Pharmaceuticals
52544085001
100.0's $32.29 Tylenol with Codeine #2
Janssen Pharmaceuticals
00045051160
100.0's $33.26 GENERIC
Barr Laboratories Inc
51285030202
100.0's $33.26 GENERIC
Barr Laboratories Inc
00555030502
500.0's $32.80 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company
53489015905
500.0's $35.65 GENERIC
Major Pharmaceuticals Inc
00904057140
1000.0's $55.20 GENERIC
Major Pharmaceuticals Inc
00904057180
1000.0's $289.08 GENERIC
Mallinckrodt Medical Inc
00406048310
1000.0's $289.18 GENERIC
Teva Pharmaceuticals USA
00093005010
tablet - oral - 300 mg- 30 mg -
6.0's $2.58 GENERIC
PD- RX Pharmaceuticals
55289000506
10.0's $2.70 GENERIC
PD- RX Pharmaceuticals
55289000510
10.0's $6.35 GENERIC
Direct Dispensing Inc
57866322701
10.0's $36.12 GENERIC
Mallinckrodt Medical Inc
00406048462
12.0's $2.78 GENERIC
PD- RX Pharmaceuticals
55289000512
12.0's $7.73 GENERIC
Cardinal Pharmaceuticals
63874020212
15.0's $2.96 GENERIC
PD- RX Pharmaceuticals
55289000515
20.0's $3.90 GENERIC
PD- RX Pharmaceuticals
55289000520
20.0's $10.25 GENERIC
Direct Dispensing Inc
57866322702
24.0's $4.32 GENERIC
PD- RX Pharmaceuticals
55289000524
25.0's $8.25 GENERIC
PD- RX Pharmaceuticals
55289000597
30.0's $3.99 GENERIC
Qualitest Pharmaceuticals Inc
00603233816
30.0's $4.93 GENERIC
PD- RX Pharmaceuticals
55289000530
30.0's $7.21 GENERIC
Golden State Medical Supply
60429050030
30.0's $12.04 GENERIC
Able Laboratories Inc
53265028503
30.0's $16.00 GENERIC
Direct Dispensing Inc
57866322703
31.0's x 10.0 $100.04 GENERIC
Vangard Labs Inc
00615043063
50.0's $18.08 GENERIC
Qualitest Pharmaceuticals Inc
00603233819
60.0's $21.68 GENERIC
Qualitest Pharmaceuticals Inc
00603233820
60.0's $30.30 GENERIC
Direct Dispensing Inc
57866322707
90.0's $32.53 GENERIC
Qualitest Pharmaceuticals Inc
00603233802
90.0's $53.00 GENERIC
Direct Dispensing Inc
57866322708
90.0's $60.00 GENERIC
UDL Laboratories Inc
51079016199
100.0's $9.38 GENERIC
Century Pharmaceuticals Inc
00436018201
100.0's $12.60 GENERIC
Purepac Pharmaceutical Company
00228200110
100.0's $12.60 GENERIC
IVAX Corporation
00182094801
100.0's $14.06 GENERIC
Qualitest Pharmaceuticals Inc
00603233821
100.0's $14.67 GENERIC
Roxane Laboratories Inc
00054802225
100.0's $16.25 GENERIC
Major Pharmaceuticals Inc
00904017561
100.0's $17.02 GENERIC
Barr Laboratories Inc
00555030302
100.0's $18.24 GENERIC
IVAX Corporation
00182094889
100.0's $21.41 GENERIC
Vintage Pharmaceuticals Inc
00254206428
100.0's $22.13 GENERIC
Sandoz Inc
00781175213
100.0's $22.13 GENERIC
Roxane Laboratories Inc
00054802224
100.0's $25.19 GENERIC
Vangard Labs Inc
00615043029
100.0's $26.12 GENERIC
Watson Pharmaceuticals
52544085101
100.0's $27.23 GENERIC
UDL Laboratories Inc
51079016120
100.0's $28.43 GENERIC
Major Pharmaceuticals Inc
00904017560
100.0's $28.59 GENERIC
UDL Laboratories Inc
51079016121
100.0's $36.10 GENERIC
Purepac Pharmaceutical Company
00228305611
100.0's $36.10 GENERIC
Purepac Pharmaceutical Company
00228302010
100.0's $36.12 GENERIC
Mallinckrodt Medical Inc
00406048401
100.0's $36.14 GENERIC
Barr Laboratories Inc
51285030302
100.0's $36.14 GENERIC
Teva Pharmaceuticals USA
00093015001
100.0's $36.14 GENERIC
Able Laboratories Inc
53265028510
100.0's $54.68 Tylenol with Codeine #3
Janssen Pharmaceuticals
00045051360
120.0's $43.37 GENERIC
Qualitest Pharmaceuticals Inc
00603233822
120.0's $44.40 GENERIC
Direct Dispensing Inc
57866322706
150.0's $53.31 GENERIC
Sky Pharmaceuticals Packaging Inc
63739000415
300.0's $81.69 GENERIC
UDL Laboratories Inc
51079016124
500.0's $148.50 GENERIC
Able Laboratories Inc
53265028550
500.0's $236.63 Tylenol with Codeine #3
Janssen Pharmaceuticals
00045051370
500.0's $260.51 Tylenol with Codeine #3
Janssen Pharmaceuticals
00045051372
1000.0's $90.00 GENERIC
Century Pharmaceuticals Inc
00436018210
1000.0's $99.85 GENERIC
Purepac Pharmaceutical Company
00228200196
1000.0's $119.00 GENERIC
Roxane Laboratories Inc
00054402231
1000.0's $169.75 GENERIC
Vintage Pharmaceuticals Inc
00254206438
1000.0's $218.93 GENERIC
Major Pharmaceuticals Inc
00904017580
1000.0's $239.00 GENERIC
Watson Pharmaceuticals
52544085110
1000.0's $275.93 GENERIC
Barr Laboratories Inc
51285030305
1000.0's $284.30 GENERIC
Purepac Pharmaceutical Company
00228305696
1000.0's $284.30 GENERIC
Purepac Pharmaceutical Company
00228302096
1000.0's $284.30 GENERIC
Mallinckrodt Medical Inc
00406048410
1000.0's $284.30 GENERIC
Able Laboratories Inc
53265028511
1000.0's $284.34 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company
00677171510
1000.0's $284.34 GENERIC
Qualitest Pharmaceuticals Inc
00603233832
1000.0's $284.35 GENERIC
Barr Laboratories Inc
00555030305
1000.0's $284.35 GENERIC
Teva Pharmaceuticals USA
00093015010
1000.0's $383.25 Tylenol with Codeine #3
Janssen Pharmaceuticals
00045051380
tablet - oral - 300 mg- 60 mg -
30.0's $20.20 GENERIC
Direct Dispensing Inc
57866322601
100.0's $17.39 GENERIC
Vangard Labs Inc
00615043201
100.0's $19.10 GENERIC
Sandoz Inc
00781165401
100.0's $19.10 GENERIC
Purepac Pharmaceutical Company
00228200310
100.0's $19.14 GENERIC
IVAX Corporation
00182133801
100.0's $20.00 GENERIC
Vangard Labs Inc
00615043213
100.0's $22.85 GENERIC
IVAX Corporation
00182133889
100.0's $26.74 GENERIC
Major Pharmaceuticals Inc
00904391661
100.0's $32.48 GENERIC
Vintage Pharmaceuticals Inc
00254206528
100.0's $36.25 GENERIC
Mallinckrodt Medical Inc
00406048501
100.0's $50.92 GENERIC
Major Pharmaceuticals Inc
00904391660
100.0's $57.10 GENERIC
UDL Laboratories Inc
51079010620
100.0's $59.96 GENERIC
UDL Laboratories Inc
51079010621
100.0's $63.80 GENERIC
Purepac Pharmaceutical Company
00228305811
100.0's $63.80 GENERIC
Purepac Pharmaceutical Company
00228302110
100.0's $63.87 GENERIC
Barr Laboratories Inc
51285030402
100.0's $63.87 GENERIC
Barr Laboratories Inc
00555030402
100.0's $63.87 GENERIC
Teva Pharmaceuticals USA
00093035001
100.0's $63.87 GENERIC
Watson Pharmaceuticals
52544085201
100.0's $63.88 GENERIC
Qualitest Pharmaceuticals Inc
00603233921
100.0's $96.61 Tylenol with Codeine #4
Janssen Pharmaceuticals
00045051560
500.0's $82.50 GENERIC
Sandoz Inc
00781165405
500.0's $85.10 GENERIC
Purepac Pharmaceutical Company
00228200350
500.0's $110.20 GENERIC
Vangard Labs Inc
00615043205
500.0's $126.20 GENERIC
Qualitest Pharmaceuticals Inc
00603233928
500.0's $144.65 GENERIC
Vintage Pharmaceuticals Inc
00254206535
500.0's $172.50 GENERIC
Mallinckrodt Medical Inc
00406048505
500.0's $197.39 GENERIC
United Research Laboratories/ Mutual Pharmaceutical Company
00677063205
500.0's $218.93 GENERIC
Major Pharmaceuticals Inc
00904391640
500.0's $275.85 GENERIC
Purepac Pharmaceutical Company
00228305850
500.0's $275.85 GENERIC
Purepac Pharmaceutical Company
00228302150
500.0's $275.93 GENERIC
Barr Laboratories Inc
51285030404
500.0's $275.93 GENERIC
Teva Pharmaceuticals USA
00093035005
500.0's $275.93 GENERIC
Watson Pharmaceuticals
52544085205
500.0's $417.36 Tylenol with Codeine #4
Janssen Pharmaceuticals
00045051570
1000.0's $535.31 GENERIC
Teva Pharmaceuticals USA
00093035010

PRODUCT LISTING - EQUIVALENTS NOT AVAILABLE

 
liquid - oral - 120 mg- 12 mg/ 5 ml -
5.0 ml $3.48 GENERIC
Prescript Pharmaceuticals
00247023405
10.0 ml $3.62 GENERIC
Prescript Pharmaceuticals
00247023410
15.0 ml $3.75 GENERIC
Prescript Pharmaceuticals
00247023415
25.0 ml $4.02 GENERIC
Prescript Pharmaceuticals
00247023425
30.0 ml $4.15 GENERIC
Prescript Pharmaceuticals
00247023430
60.0 ml $1.78 GENERIC
Allscripts Healthcare Solutions
54569401401
60.0 ml $4.95 GENERIC
Prescript Pharmaceuticals
00247023460
90.0 ml $5.75 GENERIC
Prescript Pharmaceuticals
00247023490
118.0 ml $6.49 GENERIC
Prescript Pharmaceuticals
00247023452
120.0 ml $6.54 GENERIC
Prescript Pharmaceuticals
00247023477
120.0 ml $6.59 GENERIC
Quality Care Pharmaceuticals Inc
60346087704
120.0 ml $7.01 GENERIC
Allscripts Healthcare Solutions
54569100100
120.0 ml $7.45 GENERIC
Pharma Pac
52959141603
120.0 ml $7.73 GENERIC
Physicians Total Care
54868037801
120.0 ml $18.53 GENERIC
Pharma Pac
52959014103
180.0 ml $8.14 GENERIC
Prescript Pharmaceuticals
00247023459
200.0 ml $8.67 GENERIC
Prescript Pharmaceuticals
00247023479
237.0 ml $9.66 GENERIC
Prescript Pharmaceuticals
00247023423
473.0 ml $15.94 GENERIC
Prescript Pharmaceuticals
00247023438
480.0 ml $12.48 GENERIC
Mikart Inc
46672056116
480.0 ml $14.21 GENERIC
Allscripts Healthcare Solutions
54569401400
480.0 ml $18.00 GENERIC
Hi- Tech Pharmacal Company Inc
50383007916
480.0 ml $18.07 GENERIC
Physicians Total Care
54868037802
480.0 ml $19.28 GENERIC
Major Pharmaceuticals Inc
00904777516
946.0 ml $28.52 GENERIC
Prescript Pharmaceuticals
00247023494
tablet - oral - 300 mg- 15 mg -
6.0's $3.67 GENERIC
Prescript Pharmaceuticals
00247009906
10.0's $3.88 GENERIC
Prescript Pharmaceuticals
00247009910
12.0's $3.63 GENERIC
Allscripts Healthcare Solutions
54569031100
12.0's $3.99 GENERIC
Prescript Pharmaceuticals
00247009912
12.0's $4.14 GENERIC
Southwood Pharmaceuticals Inc
58016026912
15.0's $4.15 GENERIC
Prescript Pharmaceuticals
00247009915
15.0's $5.67 GENERIC
Pharma Pac
52959020815
15.0's $7.92 GENERIC
Southwood Pharmaceuticals Inc
58016026915
16.0's $4.20 GENERIC
Prescript Pharmaceuticals
00247009916
20.0's $1.63 GENERIC
Allscripts Healthcare Solutions
54569031103
20.0's $4.41 GENERIC
Prescript Pharmaceuticals
00247009920
20.0's $10.60 GENERIC
Southwood Pharmaceuticals Inc
58016026920
24.0's $4.62 GENERIC
Prescript Pharmaceuticals
00247009924
24.0's $11.50 GENERIC
Southwood Pharmaceuticals Inc
58016026924
30.0's $4.94 GENERIC
Prescript Pharmaceuticals
00247009930
30.0's $9.06 GENERIC
Allscripts Healthcare Solutions
54569031102
30.0's $15.70 GENERIC
Southwood Pharmaceuticals Inc
58016026930
40.0's $7.03 GENERIC
Physicians Total Care
54868213001
50.0's $6.00 GENERIC
Prescript Pharmaceuticals
00247009950
100.0's $8.65 GENERIC
Prescript Pharmaceuticals
00247009900
100.0's $26.65 GENERIC
Southwood Pharmaceuticals Inc
58016026900
500.0's $29.82 GENERIC
Prescript Pharmaceuticals
00247009998
tablet - oral - 300 mg- 30 mg -
2.0's $3.62 GENERIC
Prescript Pharmaceuticals
00247007802
3.0's $3.75 GENERIC
Prescript Pharmaceuticals
00247007803
4.0's $3.88 GENERIC
Prescript Pharmaceuticals
00247007804
4.0's $9.78 GENERIC
Pharma Pac
52959000304
5.0's $4.01 GENERIC
Prescript Pharmaceuticals
00247007805
6.0's $0.76 GENERIC
Allscripts Healthcare Solutions
54569002506
6.0's $3.58 GENERIC
Southwood Pharmaceuticals Inc
58016027106
6.0's $4.15 GENERIC
Prescript Pharmaceuticals
00247007806
6.0's $10.21 GENERIC
Pharma Pac
52959000306
8.0's $0.86 GENERIC
Allscripts Healthcare Solutions
54569252303
8.0's $4.41 GENERIC
Prescript Pharmaceuticals
00247007808
8.0's $4.78 GENERIC
Southwood Pharmaceuticals Inc
58016027108
10.0's $3.60 GENERIC
Allscripts Healthcare Solutions
54569002500
10.0's $4.21 GENERIC
Physicians Total Care
54868007209
10.0's $4.68 GENERIC
Prescript Pharmaceuticals
00247007810
10.0's $5.98 GENERIC
Southwood Pharmaceuticals Inc
58016027110
10.0's $10.63 GENERIC
Pharma Pac
52959000310
12.0's $1.51 GENERIC
Allscripts Healthcare Solutions
54569002501
12.0's $4.55 GENERIC
Physicians Total Care
54868007200
12.0's $4.94 GENERIC
Prescript Pharmaceuticals
00247007812
12.0's $7.18 GENERIC
Southwood Pharmaceuticals Inc
58016027112
12.0's $11.83 GENERIC
Pharma Pac
52959000312
14.0's $8.38 GENERIC
Southwood Pharmaceuticals Inc
58016027114
15.0's $1.89 GENERIC
Allscripts Healthcare Solutions
54569002502
15.0's $2.60 GENERIC
Pharmaceutical Corporation of America
51655080254
15.0's $5.05 GENERIC
Physicians Total Care
54868007202
15.0's $5.34 GENERIC
Prescript Pharmaceuticals
00247007815
15.0's $8.98 GENERIC
Southwood Pharmaceuticals Inc
58016027115
15.0's $12.50 GENERIC
Pharma Pac
52959000315
16.0's $5.47 GENERIC
Prescript Pharmaceuticals
00247007816
16.0's $5.78 GENERIC
Allscripts Healthcare Solutions
54569252301
16.0's $10.34 GENERIC
Southwood Pharmaceuticals Inc
58016027116
16.0's $14.03 GENERIC
Pharma Pac
52959000316
18.0's $2.27 GENERIC
Allscripts Healthcare Solutions
54569252302
18.0's $10.76 GENERIC
Southwood Pharmaceuticals Inc
58016027118
20.0's $2.52 GENERIC
Allscripts Healthcare Solutions
54569002503
20.0's $5.92 GENERIC
Physicians Total Care
54868007203
20.0's $6.00 GENERIC
Prescript Pharmaceuticals
00247007820
20.0's $11.76 GENERIC
Southwood Pharmaceuticals Inc
58016027120
20.0's $17.00 GENERIC
Pharma Pac
52959000320
24.0's $3.02 GENERIC
Allscripts Healthcare Solutions
54569002509
24.0's $6.53 GENERIC
Prescript Pharmaceuticals
00247007824
24.0's $14.76 GENERIC
Southwood Pharmaceuticals Inc
58016027124
24.0's $22.95 GENERIC
Pharma Pac
52959000324
25.0's $6.66 GENERIC
Prescript Pharmaceuticals
00247007825
25.0's $14.95 GENERIC
Southwood Pharmaceuticals Inc
58016027125
25.0's $24.23 GENERIC
Pharma Pac
52959000325
28.0's $7.06 GENERIC
Prescript Pharmaceuticals
00247007828
28.0's $16.64 GENERIC
Southwood Pharmaceuticals Inc
58016027128
28.0's $27.63 GENERIC
Pharma Pac
52959000328
30.0's $3.70 GENERIC
Pharmaceutical Corporation of America
51655080224
30.0's $3.78 GENERIC
Allscripts Healthcare Solutions
54569002504
30.0's $7.33 GENERIC
Prescript Pharmaceuticals
00247007830
30.0's $7.61 GENERIC
Physicians Total Care
54868007201
30.0's $17.94 GENERIC
Southwood Pharmaceuticals Inc
58016027130
30.0's $29.16 GENERIC
Pharma Pac
52959000330
36.0's $6.40 GENERIC
Allscripts Healthcare Solutions
54569002508
40.0's $5.04 GENERIC
Allscripts Healthcare Solutions
54569252300
40.0's $9.32 GENERIC
Physicians Total Care
54868007205
40.0's $23.92 GENERIC
Southwood Pharmaceuticals Inc
58016027140
40.0's $32.56 GENERIC
Pharma Pac
52959000340
42.0's $25.12 GENERIC
Southwood Pharmaceuticals Inc
58016027142
45.0's $9.31 GENERIC
Prescript Pharmaceuticals
00247007845
50.0's $6.30 GENERIC
Allscripts Healthcare Solutions
54569002505
50.0's $9.98 GENERIC
Prescript Pharmaceuticals
00247007850
50.0's $11.03 GENERIC
Physicians Total Care
54868007204
50.0's $29.90 GENERIC
Southwood Pharmaceuticals Inc
58016027150
50.0's $36.58 GENERIC
Pharma Pac
52959000350
56.0's $33.04 GENERIC
Southwood Pharmaceuticals Inc
58016027156
60.0's $12.75 GENERIC
Physicians Total Care
54868007207
60.0's $35.88 GENERIC
Southwood Pharmaceuticals Inc
58016027160
60.0's $38.56 GENERIC
Pharma Pac
52959000360
84.0's $50.23 GENERIC
Southwood Pharmaceuticals Inc
58016027184
90.0's $40.50 GENERIC
Pharma Pac
52959000390
90.0's $53.82 GENERIC
Southwood Pharmaceuticals Inc
58016027190
100.0's $12.60 GENERIC
Allscripts Healthcare Solutions
54569002507
100.0's $16.59 GENERIC
Prescript Pharmaceuticals
00247007800
100.0's $19.57 GENERIC
Physicians Total Care
54868007208
100.0's $36.14 GENERIC
Ranbaxy Pharmaceuticals
63304056201
100.0's $41.96 GENERIC
Pharma Pac
52959000300
100.0's $59.80 GENERIC
Southwood Pharmaceuticals Inc
58016027100
120.0's $50.33 GENERIC
Pharma Pac
52959000302
120.0's $71.76 GENERIC
Southwood Pharmaceuticals Inc
58016027102
500.0's $69.53 GENERIC
Prescript Pharmaceuticals
00247007898
500.0's $148.56 GENERIC
Ranbaxy Pharmaceuticals
63304056205
1000.0's $135.71 GENERIC
Prescript Pharmaceuticals
00247007899
1000.0's $284.36 GENERIC
Ranbaxy Pharmaceuticals
63304056210
tablet - oral - 650 mg- 30 mg -
100.0's $37.80 EZ III
Stewart- Jackson Pharmacal Inc
45985062501
tablet - oral - 300 mg- 60 mg -
6.0's $4.07 GENERIC
Prescript Pharmaceuticals
00247008506
8.0's $10.80 GENERIC
Southwood Pharmaceuticals Inc
58016027208
10.0's $4.54 GENERIC
Prescript Pharmaceuticals
00247008510
10.0's $10.39 GENERIC
Southwood Pharmaceuticals Inc
58016027210
12.0's $4.79 GENERIC
Prescript Pharmaceuticals
00247008512
12.0's $7.66 GENERIC
Allscripts Healthcare Solutions
54569030207
12.0's $12.46 GENERIC
Southwood Pharmaceuticals Inc
58016027212
15.0's $2.87 GENERIC
Allscripts Healthcare Solutions
54569030206
15.0's $3.50 GENERIC
Pharmaceutical Corporation of America
51655081654
15.0's $5.14 GENERIC
Prescript Pharmaceuticals
00247008515
15.0's $15.56 GENERIC
Southwood Pharmaceuticals Inc
58016027215
16.0's $5.26 GENERIC
Prescript Pharmaceuticals
00247008516
20.0's $5.74 GENERIC
Prescript Pharmaceuticals
00247008520
20.0's $12.77 GENERIC
Allscripts Healthcare Solutions
54569030200
20.0's $20.40 GENERIC
Southwood Pharmaceuticals Inc
58016027220
20.0's $22.50 GENERIC
Pharma Pac
52959044620
24.0's $6.21 GENERIC
Prescript Pharmaceuticals
00247008524
24.0's $26.52 GENERIC
Pharma Pac
52959044624
28.0's $29.09 GENERIC
Southwood Pharmaceuticals Inc
58016027228
30.0's $5.45 GENERIC
Pharmaceutical Corporation of America
51655081624
30.0's $6.93 GENERIC
Prescript Pharmaceuticals
00247008530
30.0's $19.16 GENERIC
Allscripts Healthcare Solutions
54569030201
30.0's $28.98 GENERIC
Pharma Pac
52959044630
30.0's $30.60 GENERIC
Southwood Pharmaceuticals Inc
58016027230
40.0's $41.56 GENERIC
Southwood Pharmaceuticals Inc
58016027240
50.0's $9.31 GENERIC
Prescript Pharmaceuticals
00247008550
50.0's $9.55 GENERIC
Allscripts Healthcare Solutions
54569030204
50.0's $51.96 GENERIC
Southwood Pharmaceuticals Inc
58016027250
56.0's $58.18 GENERIC
Southwood Pharmaceuticals Inc
58016027256
60.0's $62.34 GENERIC
Southwood Pharmaceuticals Inc
58016027260
60.0's $62.50 GENERIC
Pharma Pac
52959044660
84.0's $87.28 GENERIC
Southwood Pharmaceuticals Inc
58016027284
100.0's $15.27 GENERIC
Prescript Pharmaceuticals
00247008500
100.0's $63.87 GENERIC
Allscripts Healthcare Solutions
54569030203
100.0's $96.75 GENERIC
Pharma Pac
52959044600
100.0's $103.90 GENERIC
Southwood Pharmaceuticals Inc
58016027200
120.0's $124.68 GENERIC
Southwood Pharmaceuticals Inc
58016027202
500.0's $62.92 GENERIC
Prescript Pharmaceuticals
00247008598
500.0's $275.93 GENERIC
Barr Laboratories Inc
00555030404

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