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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Colitis, pseudomembranous |
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Endocarditis |
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Enterocolitis |
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Infection, bone |
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Infection, lower respiratory tract |
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Infection, skin and skin structure |
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Septicemia |
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SIDE EFFECTS:
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difficulty in breathing |
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drowsiness |
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fever |
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increased thirst |
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loss of appetite |
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loss of hearing |
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nausea or vomiting |
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ringing or buzzing or a feeling of fullness in the ears |
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weakness |
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Nephrotoxicity |
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neutropenia |
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"red man syndrome" |
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Chemical peritonitis |
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linear IgA bullous dermatosis |
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ototoxicity |
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pseudomembranous colitis |
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thrombocytopenia |
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Abdominal or stomach cramps and pain, severe |
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abdominal tenderness |
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change in frequency of urination or amount of urine |
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diarrhea, watery and severe, which may also be bloody |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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Hypersensitivity to vancomycin |
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>> Loss of hearing, or deafness |
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>> Renal function impairment |
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ADULT DOSE:
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Antibacterial, treatment-
Intravenous infusion, 7.5 mg (base) per kg of body weight or 500 mg every six hours; or 15 mg per kg of body weight or 1 gram every twelve hours .
Note: After an initial loading dose of 750 mg to 1 gram (base), but not less than 15 mg per kg of body weight, adults with impaired renal function may require a reduction in dose as indicated in the table below. However, the preferred method is to adjust dosage based on serum vancomycin concentrations.
Creatinine clearance (mL/min)/(mL/sec) Intravenous dose (base)
> 80/1.33 See
50-80/0.83-1.33 1 gram every 1 to 3 days
10-50/0.17-0.83 1 gram every 3 to 7 days
< 10/0.17 1 gram every 7 to 14 days
[Endocarditis, prophylaxis, in penicillin-allergic patients with prosthetic heart valves or congenital, rheumatic, or other acquired valvular heart disease who are undergoing gastrointestinal or genitourinary tract procedures] -
Intravenous infusion, 1 gram (base) over a period of one to two hours, with or without gentamicin (administered intramuscularly or intravenously at a dose of 1.5 mg per kg of body weight up to 120 mg), depending on risk of bacterial endocarditis; the infusion/injection should be completed within one-half hour of the start of surgery . |
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MAXIMUM ADULT DOSE:
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3 to 4 grams (base) a day have been used intravenously for short periods of time in very severe infections.
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PEDIATRIC DOSE:
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Antibacterial, treatment-
Neonates up to 1 week of age: Intravenous infusion, 15 mg (base) per kg of body weight initially, followed by 10 mg per kg of body weight every twelve hours .
Infants 1 week to 1 month of age: Intravenous infusion, 15 mg (base) per kg of body weight initially, followed by 10 mg per kg of body weight every eight hours .
Infants and children 1 month to 12 years of age: Intravenous infusion, 10 mg (base) per kg of body weight every six hours ; or 20 mg per kg of body weight every twelve hours.
Note: Doses of up to 60 mg (base) per kg of body weight per day have been used in some infections (e.g., staphylococcal infections of the central nervous system [CNS]).
[Endocarditis, prophylaxis, in penicillin-allergic patients with prosthetic heart valves or congenital, rheumatic, or other acquired valvular heart disease who are undergoing gastrointestinal or genitourinary tract procedures] -
Intravenous infusion, 20 mg (base) per kg of body weight over a period of one to two hours, with or without gentamicin (administered intramuscularly or intravenously at a dose of 1.5 mg per kg of body weight), depending on degree of risk; the infusion/injection should be completed within one-half hour of the start of surgery . |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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