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TRIMOL DS TABLETS

 

 
 

 

GENERIC NAMES

MANUFACTURERS 

MEDICAL GROUP

MEDICAL ARTICLES

 

DRUGS IN :

 

 

FDA DRUGS

UNITED STATES

CANADA

UNITED KINGDOM

AUSTRALIA

GERMANY

FRANCE

MIDDLE EAST

KUWAIT

LEBANON

EGYPT

SYRIA

BAHRAIN

IRAN

JORDAN

SAUDI ARABIA

UNITED ARAB EMIRATES

 

 

 
 

SIZE:

 

GENERIC NAME:

SULFAMETHOXAZOLE AND TRIMETHOPRIM

 

MANUFACTURER:

JULPHAR

 

UNIT:

 

ADMINISTRATION ROUTE:

 

FDA PREGNANCY GROUP:

C

 

INDICATIONS:

Shigellosis

Bronchitis, chronic, acute exacerbation

Diarrhea, infectious

Infection, ear, middle

Infection, lower respiratory tract

Infection, urinary tract

Pneumonia, pneumocystis carinii

 

SIDE EFFECTS:

Hypersensitivity

photosensitivity

Blood dyscrasias

cholestatic hepatitis

pancreatitis

Stevens-Johnson syndrome

toxic epidermal necrolysis

Aseptic meningitis

central nervous system (CNS) toxicity

Clostridium difficile colitis

crystalluria or hematuria

goiter or thyroid function disturbance

interstitial nephritis or tubular necrosis

methemoglobinemia

rhabdomyolysis

thrombophlebitis

CNS effects

gastrointestinal disturbances

glossitis or stomatitis

 

ABSOLUTE CONTRAINDICATIONS :

 

RELATIVE CONTRAINDICATIONS :

>> Blood dyscrasias

>> Megaloblastic anemia due to folate deficiency

>> Glucose-6-phosphate dehydrogenase deficiency

>> Hepatic function impairment

>> Porphyria

>> Renal function impairment

 

ADULT DOSE:

Antibacterial (systemic)- Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim every twelve hours. Antiprotozoal- Pneumocystis carinii pneumonia - Treatment: Oral, 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg of body weight every six hours for fourteen to twenty-one days . Prophylaxis : Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim once a day. Acceptable alternative dosing schedules include- Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim three times a week (e.g., Monday, Wednesday, Friday) . Oral, 400 mg of sulfamethoxazole and 80 mg of trimethoprim once a day . [Toxoplasmosis (prophylaxis)] - Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim once a day. Acceptable alternative dosing schedules include: Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim three times a week (e.g., Monday, Wednesday, Friday) . Oral, 400 mg of sulfamethoxazole and 80 mg of trimethoprim once a day. [ HIV-related infection in Africa (prophylaxis)] - Oral, 800 mg of sulfamethoxazole and 160 mg of trimethoprim once a day .

 

MAXIMUM ADULT DOSE:

 

PEDIATRIC DOSE:

Antibacterial (systemic)- Infants up to 2 months of age- Use is not recommended since sulfonamides may cause kernicterus in neonates. Infants 2 months of age and over- Infants and children up to 40 kg of body weight-Oral, 20 to 30 mg of sulfamethoxazole and 4 to 6 mg of trimethoprim per kg of body weight every twelve hours. Children 40 kg of body weight and over-See Usual adult and adolescent dose. Antiprotozoal- Pneumocystis carinii pneumonia (PCP)- Treatment: Oral, 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg of body weight every six hours for fourteen to twenty-one days. Prophylaxis : Children 4 weeks of age and over- Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day, three times a week on consecutive days (e.g., Monday, Tuesday, Wednesday). Acceptable alternative dosing schedules include - Oral, 750 mg of sulfamethoxazole per square meter and 150 mg of trimethoprim per square meter of body surface as a single daily dose three times a week on consecutive days (e.g., Monday, Tuesday, Wednesday). Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day seven days a week. Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day, three times a week on alternate days (e.g., Monday, Wednesday, Friday). Note: PCP prophylaxis is recommended for all infants born to HIV-infected mothers starting at 4 weeks of age, regardless of their CD4 lymphocyte counts. However, if the infant is receiving zidovudine during the first 6 weeks of life for the prevention of perinatal HIV transmission, sulfamethoxazole and trimethoprim combination prophylaxis should be delayed until zidovudine is discontinued at 6 weeks of age, to reduce the chance of anemia that may occur if these two medications are given concurrently. [Toxoplasmosis (prophylaxis)] - Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day, three times a week on consecutive days (e.g., Monday, Tuesday, Wednesday). Acceptable alternative dosing schedules include: Oral, 750 mg of sulfamethoxazole per square meter and 150 mg of trimethoprim per square meter of body surface as a single daily dose three times a week on consecutive days (e.g., Monday, Tuesday, Wednesday). Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day seven days a week. Oral, 375 mg of sulfamethoxazole per square meter and 75 mg of trimethoprim per square meter of body surface two times a day, three times a week on alternate days (e.g., Monday, Wednesday, Friday). [HIV-related infection in Africa (prophylaxis)] - Studies have not been performed in children . 

 

MAXIMUM PEDIATRIC DOSE:

 

ELDERLY DOSE:

 

 

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