SANDOSTATIN INJECTION

Gastrointestinal tumors- Subcutaneous, 50 mcg initially, administered two or three times a day, the dose being increased gradually according to patient tolerance and response. The following dosages are recommended for specific tumors: Carcinoid tumors- Initial: Subcutaneous, 100 to 600 mcg per day, administered in two to four divided doses, for the first two weeks of therapy. Maintenance: Subcutaneous, 50 to 1500 mcg per day. In clinical trials, the median maintenance dosage was 450 mcg per day. Vasoactive intestinal polypeptide-secreting tumors (VIPomas): Subcutaneous, 200 to 300 mcg per day, administered in two to four divided doses, for the first two weeks of therapy. Dosage may then be increased based on patient response. Acromegaly- Subcutaneous or intravenous, initially 50 mcg three times a day. Dosage is titrated every two weeks as needed, according to IGF-I concentrations, to a dose of 100 to 200 mcg three times a day; or, for rapid titration, dosage increase may be based on multiple serum growth hormone concentrations taken at one- to four-hour intervals over eight to twelve hours. Doses of up to 500 mcg three times a day have been used rarely. Note: Octreotide injection may be administered subcutaneously (the preferred route) or intravenously. To help prevent pain at the injection site, octreotide should be given in the smallest volume needed to achieve the proper dose. In emergencies, intravenous injections may be used cautiously. If an increase in dose fails to provide additional benefit, the dose should be reduced. [Complications of pancreatic surgery (prophylaxis of)]- Subcutaneous, 100 mcg three times a day for seven days beginning on the day of surgery at least one hour before laparatomy. [Bleeding gastroesophageal varices]- Intravenous infusion, 25 mcg per hour for forty-eight hours. Infusion should continue for up to five days in patients at high risk for rebleeding. [Pancreatic tumors] - Subcutaneous, 50 to 150 mcg initially, administered two times a day thirty minutes before meals, the dose being increased gradually according to patient tolerance and response. [Acquired immunodeficiency syndrome (AIDS)-associated diarrhea] - Subcutaneous, 100 to 1800 mcg per day.

MAXIMUM ADULT DOSE:

Acromegaly-1500 mcg daily.

PEDIATRIC DOSE:

Gastrointestinal tumors- Subcutaneous, 1 to 10 mcg per kg of body weight per day.

MAXIMUM PEDIATRIC DOSE:

ELDERLY DOSE:

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