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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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B
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INDICATIONS:
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Trichomoniasis |
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Abscess, brain |
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Abscess, intra- abdominal |
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Abscess, liver |
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Abscess, lung |
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Abscess, tubo- ovarian |
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Acne rosacea |
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Amebiasis |
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Empyema |
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Endocarditis |
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Endometritis |
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Endomyometritis |
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Infection, anaerobic bacterial |
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Infection, bone |
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Infection, central nervous system |
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Infection, gynecologic |
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Infection, intra- abdominal |
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Infection, joint |
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Infection, lower respiratory tract |
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Infection, skin and skin structure |
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Infection, vaginal cuff |
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Meningitis |
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Peritonitis |
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Pneumonia |
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Prophylaxis, surgical |
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Septicemia |
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SIDE EFFECTS:
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Peripheral neuropathy |
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seizures |
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CNS toxicity |
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hypersensitivity |
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leukopenia |
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pancreatitis |
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thrombocytopenia |
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thrombophlebitis |
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Urinary tract effects |
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vaginal candidiasis |
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CNS effects |
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gastrointestinal disturbance |
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Change in taste sensation |
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dryness of mouth |
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unpleasant or sharp metallic taste |
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Dark urine |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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>> Active organic disease of the CNS, including epilepsy |
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>> Blood dyscrasias |
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Cardiac function impairment |
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>> Hepatic function impairment, severe |
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Hypersensitivity to metronidazole |
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>> Known or previously unrecognized candidiasis |
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ADULT DOSE:
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Antibacterial (systemic)-
Anaerobic infections: Oral, 7.5 mg (base) per kg of body weight, up to a maximum of 1 gram, every six hours for seven days or longer.
[Bowel disease, inflammatory ] : Oral, 500 mg (base) four times a day.
[Colitis, antibiotic-associated] : Oral, 500 mg (base) three or four times a day.
[Gastritis, Helicobacter pylori -associated (treatment adjunct)] or
[Ulcer, duodenal, Helicobacter pylori -associated (treatment adjunct)] -Oral, 500 mg (base) three times a day, in conjunction with bismuth subsalicylate or colloidal bismuth subcitrate and other oral antibiotic therapy, such as ampicillin or amoxicillin, for one to two weeks.
[Vaginosis, bacterial] : Oral, 500 mg (base) two times a day for seven days.
Antiprotozoal-
Amebiasis: Oral, 500 to 750 mg (base) three times a day for five to ten days.
Amebic liver abscess: Oral, 500 to 750 mg (base) three times a day for five to ten days.
[Balantidiasis] : Oral, 750 mg (base) three times a day for five or six days.
[Giardiasis] : Oral, 2 grams (base) once a day for three days; or 250 mg three times a day for five to seven days.
Trichomoniasis: Oral, 2 grams (base) as a single dose; 1 gram two times a day for one day; 375 mg two times a day for seven days; or 250 mg three times a day for seven days.
Anthelmintic (systemic)-
[Dracunculiasis] : Oral, 250 mg (base) three times a day for ten days. |
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MAXIMUM ADULT DOSE:
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Antibacterial (systemic)-
Up to a maximum of 4 grams (base) daily. |
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PEDIATRIC DOSE:
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Antibacterial (systemic)-
Anaerobic infections : Oral, 7.5 mg (base) per kg of body weight every six hours, or 10 mg per kg of body weight every eight hours.
Antiprotozoal-
Amebiasis: Oral, 11.6 to 16.7 mg (base) per kg of body weight three times a day for ten days.
[ Balantidiasis] : Oral, 11.6 to 16.7 mg (base) per kg of body weight three times a day for five days.
[Giardiasis] : Oral, 5 mg (base) per kg of body weight three times a day for five to seven days.
Trichomoniasis: Oral, 5 mg (base) per kg of body weight three times a day for seven days.
Anthelmintic (systemic)-
[Dracunculiasis] : Oral, 8.3 mg (base) per kg of body weight, up to a maximum of 250 mg, three times a day for ten days. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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