|
|
|
|
|
SIZE:
|
|
|
|
GENERIC NAME:
|
AMOXICILLIN AND CLAVULANIC ACID
|
|
MANUFACTURER:
|
|
|
|
UNIT:
|
|
|
|
ADMINISTRATION ROUTE:
|
|
|
|
FDA PREGNANCY GROUP:
|
|
B
|
|
INDICATIONS:
|
|
Infection, ear, middle |
|
Infection, lower respiratory tract |
|
Infection, sinus |
|
Infection, skin and skin structure |
|
Infection, upper respiratory tract |
|
Infection, urinary tract |
| |
|
|
SIDE EFFECTS:
|
|
vasculitis |
|
abdominal pain |
|
acute generalized exanthematous pustulosis (AGEP) |
|
agitation |
|
agranulocytosis |
|
anaphylactic shock |
|
anemia |
|
angioedema |
|
anorexia |
|
anxiety |
|
arthralgia |
|
bullous rash |
|
candidiasis |
|
cholestasis |
|
confusion |
|
crystalluria |
|
diarrhea |
|
dizziness |
|
dyspepsia |
|
elevated hepatic enzymes |
|
enterocolitis |
|
eosinophilia |
|
erythema multiforme |
|
exfoliative dermatitis |
|
fever |
|
gastritis |
|
glossitis |
|
headache |
|
hematuria |
|
hemolysis |
|
hemolytic anemia |
|
hepatitis |
|
insomnia |
|
interstitial nephritis |
|
jaundice |
|
leukopenia |
|
maculopapular rash |
|
myalgia |
|
nausea/vomiting |
|
nephrotic syndrome |
|
neutropenia |
|
oliguria |
|
platelet dysfunction |
|
prolonged bleeding time |
|
pruritus |
|
pseudomembranous colitis |
|
purpura |
|
seizures |
|
serum sickness |
|
Stevens-Johnson syndrome |
|
stomatitis |
|
superinfection |
|
thrombocytopenia |
|
tongue discoloration |
|
tooth discoloration |
|
toxic epidermal necrolysis |
|
urticaria |
|
|
ABSOLUTE
CONTRAINDICATIONS :
|
|
|
|
RELATIVE
CONTRAINDICATIONS : |
|
asthma |
|
breast-feeding |
|
carbapenem hypersensitivity |
|
cephalosporin hypersensitivity |
|
cholestasis |
|
colitis |
|
diabetes mellitus |
|
dialysis |
|
diarrhea |
|
eczema |
|
GI disease |
|
hepatic disease |
|
infants |
|
infection |
|
jaundice |
|
leukemia |
|
mononucleosis |
|
neonates |
|
phenylketonuria |
|
pregnancy |
|
renal failure |
|
renal impairment |
|
|
ADULT DOSE:
|
|
Antibacterial-
Pneumonia and other severe infections-
Oral, 875 mg of amoxicillin and 125 mg of clavulanic acid every twelve hours or 500 mg of amoxicillin and 125 mg of clavulanic acid every eight hours.
Other infections-
Oral, 500 mg of amoxicillin and 125 mg of clavulanic acid every twelve hours or 250 mg of amoxicillin and 125 mg of clavulanic acid every eight hours.
Note: Adults who have difficulty swallowing may be given the 125-mg-per-5 mL or the 250-mg-per-5 mL formulation of oral suspension in place of the 500-mg tablet. The 200-mg-per-5 mL or the 400-mg-per-5 mL formulation of oral suspension may be used in place of the 875-mg tablet. |
|
MAXIMUM ADULT DOSE:
|
|
|
|
PEDIATRIC DOSE:
|
|
Antibacterial-
Dosage is based on the amoxicillin component.
Neonates and infants up to 12 weeks (3 months) of age-
Oral, 15 mg of amoxicillin per kg of body weight every twelve hours.
Note:
Use of the formulation containing 125 mg of amoxicillin per 5 mL of oral suspension is recommended by the manufacturer since experience is limited with the 200-mg-per-5 mL formulation.
Infants 3 months of age and older and children up to 40 kg of body weight - Otitis media, acute
Pneumonia
Sinusitis
Other severe infections-
Oral, 22.5 mg of amoxicillin per kg of body weight every twelve hours (using the formulation containing either 200 mg of amoxicillin per 5 mL or 400 mg of amoxicillin per 5 mL) or 13.3 mg of amoxicillin per kg of body weight every eight hours (using the formulation containing either 125 mg of amoxicillin per 5 mL or 250 mg of amoxicillin per 5 mL).
Less severe infections-Oral, 12.5 mg of amoxicillin per kg of body weight every twelve hours (using the formulation containing either 200 mg of amoxicillin per 5 mL or 400 mg of amoxicillin per 5 mL) or 6.7 mg of amoxicillin per kg of body weight every eight hours (using the formulation containing either 125 mg of amoxicillin per 5 mL or 250 mg of amoxicillin per 5 mL).
Children weighing more than 40 kg of body weight-
See Usual adult and adolescent dose. |
|
MAXIMUM PEDIATRIC
DOSE:
|
|
|
|
ELDERLY DOSE:
|
|
|
|
|
|
|