MAXIPIME VIALS

intraabdominal infections, complicated -Intravenous, 2 grams (base), in combination with metronidazole, every twelve hours for seven to ten days . [Septicemia]or Skin and soft tissue infections, uncomplicated, moderate to severe or Urinary tract infections, severe-Intravenous, 2 grams (base) every twelve hours for ten days . Neutropenia, febrile-Intravenous, 2 grams (base) every eight hours for seven days or until resolution of neutropenia . Note: In patients whose fever resolves but who remain neutropenic for more than seven days, the need for continued antimicrobial therapy should be re-evaluated frequently . Pneumonia, moderate to severe-Intravenous, 1 to 2 grams (base) every twelve hours for ten days . Urinary tract infections, mild to moderate -Intramuscular or intravenous, 500 mg to 1 gram (base) every twelve hours for seven to ten days . Note: After an initial loading dose equal to that of patients with normal renal function, patients with renal function impairment may require a reduction in dose as follows : Creatinine clearance Recommended dosing schedule for normal renal function, based on (mL/min)/(mL/sec) severity of infection > 60/1 500 mg every 12 1 gram every 12 2 grams every 12 2 grams every 8 hours hours hours hours Recommended maintenance dosing schedule for renal function impairment, based on severity of infection 30-60/0.5-1 500 mg every 24 1 gram every 24 2 grams every 24 2 grams every 12 hours hours hours hours 11-29/0.18-0.49 500 mg every 24 500 mg every 24 1 gram every 24 2 grams every 24 hours hours hours hours < 11/0.18 250 mg every 24 250 mg every 24 500 mg every 24 1 gram every 24 hours hours hours hours Hemodialysis patients Repeat the initial dose at the completion of each dialysis session. Peritoneal dialysis Administer normally recommended dose at 48-hour intervals. patients

MAXIMUM ADULT DOSE:

PEDIATRIC DOSE:

Pneumonia, moderate to severe or Skin and skin structure infection, moderate to severe, uncomplicated or- Urinary tract infection, mild or moderate, uncomplicated or complicated-Infants and children 2 months to 16 years of age (up to 40 kg of body weight): Intravenous, 50 mg per kg of body weight every 12 hours for 10 days (7 to 10 days for urinary tract infection) . Urinary tract infection, severe, uncomplicated or complicated-Infants and children 2 months to 16 years of age (up to 40 kg of body weight): Intravenous or intramuscular, 50 mg per kg of body weight every 12 hours for 7 to 10 days . Note: Intramuscular route of administration is indicated only for mild to moderate, uncomplicated or complicated urinary tract infections due to Escherichia coli in the event that intramuscular administration is determined to be the more appropriate drug administration route . Febrile neutropenia, empiric therapy-Infants and children 2 months to 16 years of age (up to 40 kg of body weight): Intravenous, 50 mg per kg of body weight every 8 hours for 7 days or until resolution of neutropenia . Note: In patients whose fever resolves but who remain neutropenic for more than seven days, the need for continued antimicrobial therapy should be re-evaluated frequently .

MAXIMUM PEDIATRIC DOSE:

The maximum pediatric dose should not exceed the dose recommended for adults .

ELDERLY DOSE:

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