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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Anemia, megaloblastic |
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Carcinoma, colorectal, adjunct |
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Osteosarcoma |
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Toxicity, methotrexate |
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SIDE EFFECTS:
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Allergic reaction |
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seizures |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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ADULT DOSE:
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Antidote (to folic acid antagonists)-
To methotrexate (inadvertent overdose)-
Intramuscular or intravenous, 10 mg (base) per square meter of body surface area every six hours until methotrexate blood concentrations fall to less than 5 ´ 10 Molar.
Note:
If, at 24 hours following methotrexate administration, the serum creatinine is increased 50% over baseline or serum methotrexate is greater than 5 ´ 10 Molar, the dose of leucovorin should be 100 mg (base) per square meter of body surface area every three hours intravenously until methotrexate concentrations are reduced to appropriate levels .
Only solutions prepared with sterile water for injection (i.e., without benzyl alcohol) should be used for doses greater than 10 mg per square meter of body surface area.
To pyrimethamine or trimethoprim-
Prevention-Intramuscular, 400 mcg (0.4 mg) to 5 mg (base) with each dose of the folic acid antagonist.
Treatment-Intramuscular, 5 to 15 mg (base) per day.
Megaloblastic anemia, secondary to folate deficiency-
Intramuscular, up to 1 mg (base) per day.
Carcinoma, colorectal (treatment adjunct) -
Intravenous, 200 mg per square meter of body surface area over a minimum of three minutes, followed by fluorouracil 370 mg per square meter of body surface area intravenously , or
Intravenous, 20 mg per square meter of body surface area, followed by fluorouracil 425 mg per square meter of body surface area intravenously .
Either regimen is given daily for five days, and the course may be repeated at four-week intervals for two courses and then at four- to five-week intervals, as determined by toxicity to the previous course .
Note: Only solutions prepared with sterile water for injection (i.e., without benzyl alcohol) should be used, since the dose is greater than 10 mg per square meter of body surface area.
Because of its calcium content, leucovorin calcium for injection should be administered by intravenous injection slowly, at a rate that does not exceed 160 mg of leucovorin per minute. |
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MAXIMUM ADULT DOSE:
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PEDIATRIC DOSE:
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Antidote (to folic acid antagonists) or
Megaloblastic anemia-See Usual adult and adolescent dose .
Carcinoma, colorectal (treatment adjunct)-Dosage has not been established. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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