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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Edema |
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Edema, pulmonary |
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Hypertension, essential |
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SIDE EFFECTS:
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hypovolemia |
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interstitial nephritis |
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jaundice |
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leukopenia |
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nausea/vomiting |
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orthostatic hypotension |
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pancreatitis |
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paresthesias |
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photosensitivity |
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polyuria |
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thrombocytopenia |
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tinnitus |
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abdominal pain |
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acute generalized exanthematous pustulosis (AGEP) |
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agranulocytosis |
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anemia |
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anorexia |
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aplastic anemia |
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azotemia |
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blurred vision |
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cholestasis |
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constipation |
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diarrhea |
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dizziness |
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headache |
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hearing loss |
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hypercholesterolemia |
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hyperglycemia |
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hypertriglyceridemia |
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hyperuricemia |
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hypocalcemia |
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hypochloremia |
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hypokalemia |
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hypomagnesemia |
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hyponatremia |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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acute myocardial infarction |
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breast-feeding |
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diabetes mellitus |
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diarrhea |
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eclampsia |
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elderly |
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gout |
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hearing impairment |
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heart failure |
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hepatic disease |
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hyperglycemia |
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hyperuricemia |
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hypocalcemia |
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hypochloremia |
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hypokalemia |
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hypomagnesemia |
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hyponatremia |
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neonatal prematurity |
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pancreatitis |
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preeclampsia |
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pregnancy |
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renal disease |
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renal failure |
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renal impairment |
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sulfonamide hypersensitivity |
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systemic lupus erythematosus (SLE) |
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thiazide diuretic hypersensitivity |
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ADULT DOSE:
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Diuretic-Intramuscular or intravenous, initially 20 to 40 mg as a single dose, the dosage then being increased by an additional 20 mg at two-hour intervals until the desired response is obtained. The maintenance dose as determined by titration is then given one or two times a day.
Note: In acute pulmonary edema (not accompanied by hypertensive crisis), the usual initial dose is 40 mg intravenously, followed by 80 mg in one hour if a satisfactory response is not obtained.
Antihypertensive-Hypertensive crisis in patients with normal renal function: Intravenous, 40 to 80 mg.
Hypertensive crisis accompanied by pulmonary edema or acute renal failure: Intravenous, 100 to 200 mg.
[Antihypercalcemic] -Intramuscular or intravenous, 80 to 100 mg in severe cases, the dosage being repeated if necessary every one to two hours until the desired response is obtained. In less severe cases, smaller doses may be given every two to four hours.
[Diagnostic aid adjunct (renal disease)]-Intravenous, 0.3 to 0.5 mg per kg of body weight to a maximum of 40 mg.
Note: Geriatric patients may be more sensitive to the effects of the usual adult dose. |
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MAXIMUM ADULT DOSE:
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Although controversial, doses of up to 6 grams a day administered by slow intravenous infusion have been used in acute renal failure by some clinicians.
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PEDIATRIC DOSE:
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Diuretic-Intramuscular or intravenous, initially 1 mg per kg of body weight as a single dose, the dosage then being increased by an additional 1 mg per kg of body weight at two-hour intervals until the desired response is obtained.
[Antihypercalcemic] -Intramuscular or intravenous, 25 to 50 mg, the dosage being repeated if necessary every four hours until the desired response is obtained.
Note: Doses greater than 6 mg per kg of body weight are not recommended.
Dosing interval should be extended in neonates because of prolonged half-life. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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