KEFZOL VIALS

[Endocarditis, prophylaxis] -Intramuscular or intravenous, 1 gram (base) one-half hour prior to the start of surgery . Perioperative prophylaxis-Intramuscular or intravenous, 1 gram (base) one-half to one hour prior to the start of surgery; 500 mg to 1 gram during surgery; and 500 mg to 1 gram every six to eight hours following surgery for up to twenty-four hours . Pneumonia, pneumococcal-Intramuscular or intravenous, 500 mg (base) every twelve hours . Urinary tract infections, acute, uncomplicated -Intramuscular or intravenous, 1 gram (base) every twelve hours . For all other infections-Mild: Intramuscular or intravenous, 250 to 500 mg (base) every eight hours . Moderate to severe: Intramuscular or intravenous, 500 mg to 1 gram (base) every six to eight hours . Severe to life-threatening: Intramuscular or intravenous, 1 to 1.5 grams (base) every six hours . Note: Adults with renal function impairment may require a reduction in dose . See Cefazolin Injection USP .

MAXIMUM ADULT DOSE:

6 grams (base) per day; however, doses of up to 12 grams per day have been used in rare instances .

PEDIATRIC DOSE:

[Endocarditis, prophylaxis] -Intramuscular or intravenous, 25 mg (base) per kg of body weight one-half hour prior to the start of surgery . For all other infections-Infants and children 1 month of age and older: Intramuscular or intravenous, 6.25 to 25 mg (base) per kg of body weight every six hours; or 8.3 to 33.3 mg per kg of body weight every eight hours . Neonates and infants up to 1 month of age: Intravenous infusion, 20 mg (base) per kg of body weight every eight to twelve hours . Note: Children with renal function impairment may require a reduction in dose . See Cefazolin Injection USP .

MAXIMUM PEDIATRIC DOSE:

1 gram (base) for prophylaxis of bacterial endocarditis .

ELDERLY DOSE:

[Endocarditis, prophylaxis] -Intravenous infusion, 1 gram (base) one-half hour prior to the start of surgery . Perioperative prophylaxis-Intravenous infusion, 1 gram (base) one-half to one hour prior to the start of surgery; 500 mg to 1 gram during surgery; and 500 mg to 1 gram every six to eight hours following surgery for up to twenty-four hours . Pneumonia, pneumococcal-Intravenous infusion, 500 mg (base) every twelve hours . Urinary tract infections, acute, uncomplicated -Intravenous infusion, 1 gram (base) every twelve hours . For all other infections-Mild: Intravenous infusion, 250 to 500 mg (base) every eight hours . Moderate to severe: Intravenous infusion, 500 mg to 1 gram (base) every six to eight hours . Severe to life-threatening: Intravenous infusion, 1 to 1.5 grams (base) every six hours . Note: After an initial loading dose appropriate to the severity of the infection, adults with impaired renal function may require a reduction in dose as follows : Creatinine clearance (mL/min)/(mL/sec) Dose (base) ³ 55/0.92 See Usual adult and adolescent dose 35-54/0.58-0.9 Full dose every 8 hours or less frequently 11-34/0.18-0.57 1/2usual dose every 12 hours £ 10/0.17 1/2usual dose every 18-24 hours

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