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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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MERCK SHARP & DOHME INTERNATIONAL
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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B; D , 3rd trimester
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INDICATIONS:
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Ankylosing spondylitis |
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Arthritis, gouty |
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Arthritis, osteoarthritis |
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Arthritis, rheumatoid |
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Bursitis |
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Patent ductus arteriosus |
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Tendonitis, shoulder |
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SIDE EFFECTS:
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abdominal pain |
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agranulocytosis |
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anaphylactic shock |
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anaphylactoid reactions |
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anemia |
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aplastic anemia |
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apnea |
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aseptic meningitis |
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azotemia |
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constipation |
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depression |
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diarrhea |
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dizziness |
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dyspepsia |
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dysphagia |
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edema |
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elevated hepatic enzymes |
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esophageal stricture |
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esophageal ulceration |
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esophagitis |
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exfoliative dermatitis |
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fatigue |
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flatulence |
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fluid retention |
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gastritis |
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GI bleeding |
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GI perforation |
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headache |
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heart failure |
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hemolytic anemia |
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hepatitis |
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hyperkalemia |
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hypertension |
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hypoglycemia |
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hyponatremia |
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infection |
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interstitial nephritis |
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intraventricular hemorrhage |
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jaundice |
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malaise |
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melena |
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nausea/vomiting |
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nephrotic syndrome |
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odynophagia |
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oliguria |
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pancytopenia |
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peptic ulcer |
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peripheral edema |
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platelet dysfunction |
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pyrosis (heartburn) |
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rash (unspecified) |
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renal papillary necrosis |
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retinopathy |
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skin irritation |
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Stevens-Johnson syndrome |
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tenesmus |
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thrombocytopenia |
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tinnitus |
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toxic epidermal necrolysis |
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urticaria |
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vertigo |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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acute bronchospasm |
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alcoholism |
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anemia |
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anticoagulant therapy |
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asthma |
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bone marrow suppression |
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breast-feeding |
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chemotherapy |
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children |
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coagulopathy |
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corticosteroid therapy |
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dehydration |
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dental disease |
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dental work |
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depression |
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diabetes mellitus |
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driving or operating machinery |
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edema |
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elderly |
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GI bleeding |
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GI disease |
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heart failure |
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hematological disease |
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hemophilia |
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hemorrhoids |
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hepatic disease |
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hypertension |
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immunosuppression |
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intramuscular injections |
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jaundice |
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labor |
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nasal polyps |
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neutropenia |
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Parkinson's disease |
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peptic ulcer disease |
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pregnancy |
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renal disease |
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renal failure |
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renal impairment |
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rheumatoid arthritis |
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seizure disorder |
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sepsis |
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surgery |
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systemic lupus erythematosus (SLE) |
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thrombocytopenia |
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tobacco smoking |
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ulcerative colitis |
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ADULT DOSE:
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Antirheumatic (nonsteroidal anti-inflammatory)
Anti-inflammatory (nonsteroidal)
Antigout agent or
[Antipyretic] -Rectal, 50 mg up to four times a day.
Note: A daily dose of less than 75 mg may not be effective in active inflammatory disease.
For those arthritic patients who have persistent night pain and/or morning stiffness, up to 100 mg of the total daily dose may be given at bedtime. Lower bedtime doses may not provide adequate symptomatic relief.
A daily dose of more than 150 to 200 mg may increase the risk of adverse effects without providing additional clinical benefit. |
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MAXIMUM ADULT DOSE:
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Rectal or combined oral and rectal, 200 mg per day.
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PEDIATRIC DOSE:
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Antirheumatic (nonsteroidal anti-inflammatory) -Rectal, 1.5 to 2.5 mg per kg of body weight per day, administered in 3 or 4 divided doses, up to a maximum of 4 mg per kg of body weight or 150 to 200 mg per day, whichever is less. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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