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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Angina pectoris |
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Arrhythmia, atrial fibrillation |
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Arrhythmia, atrial flutter |
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Arrhythmia, paroxysmal atrial tachycardia |
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Arrhythmia, secondary to thyrotoxicosis |
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Arrhythmia, supraventricular |
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Extrasystole, atrial |
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Extrasystole, premature ventricular |
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Headache, migraine, prophylaxis |
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Hypertension, essential |
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Myocardial infarction |
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Pheochromocytoma, adjunct |
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Stenosis, hypertrophic subaortic |
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Tachycardia, digitalis- induced |
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Tachycardia, sinus |
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Tachycardia, ventricular |
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Tremor, essential |
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Wolff- Parkinson- White syndrome |
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SIDE EFFECTS:
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agranulocytosis |
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alopecia |
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anaphylactoid reactions |
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AV block |
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bronchospasm |
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diabetes mellitus |
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diarrhea |
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erythema multiforme |
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exfoliative dermatitis |
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fatigue |
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fever |
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hallucinations |
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heart failure |
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hyperglycemia |
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hypertriglyceridemia |
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hypoglycemia |
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hypotension |
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impotence |
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laryngospasm |
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libido decrease |
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musculoskeletal pain |
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myalgia |
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nausea/vomiting |
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nightmares |
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pharyngitis |
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pruritus |
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sinus bradycardia |
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skin hyperpigmentation |
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Stevens-Johnson syndrome |
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toxic epidermal necrolysis |
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urticaria |
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xerosis |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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asthma |
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breast-feeding |
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bronchitis |
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cerebrovascular disease |
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chronic obstructive pulmonary disease (COPD) |
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depression |
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diabetes mellitus |
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driving or operating machinery |
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elderly |
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emphysema |
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heart failure |
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hepatic disease |
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hyperthyroidism |
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hypoglycemia |
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hypotension |
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myasthenia gravis |
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peripheral vascular disease |
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pheochromocytoma |
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pregnancy |
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psoriasis |
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pulmonary disease |
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Raynaud's disease |
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renal disease |
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renal failure |
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surgery |
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thyroid disease |
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thyrotoxicosis |
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tobacco smoking |
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vasospastic angina |
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ADULT DOSE:
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Antianginal-Oral, 80 to 320 mg per day given in two, three, or four divided doses .
Antiarrhythmic-Oral, 10 to 30 mg three or four times a day, the dosage being adjusted as needed and tolerated.
Antihypertensive-Oral, 40 mg two times a day, the dosage being increased gradually as needed and tolerated, usually 120 to 240 mg a day; doses up to a total of 640 mg a day may be necessary (a total daily dose of 1 gram has been used by some clinicians).
Hypertrophic cardiomyopathy therapy adjunct-Oral, 20 to 40 mg three or four times a day, the dosage being adjusted as needed and tolerated.
Myocardial infarction-Oral, 180 to 240 mg a day in divided doses.
Pheochromocytoma therapy adjunct-Oral, 20 mg three times a day to 40 mg three or four times a day (as necessary for sufficient beta-blockade) for three days prior to surgery, concomitantly with alpha-adrenergic blocking medication (should never be started until alpha-adrenergic blockade is at least partially established). Doses of 30 to 160 mg per day in divided doses have been used for management of inoperable tumor.
Vascular headache prophylactic-Oral, 20 mg four times a day initially, the dosage being increased gradually as needed and tolerated up to a total of 240 mg a day if necessary.
Antitremor agent-Oral, 40 mg two times a day, the dosage being adjusted as needed and tolerated, up to 120 mg a day; occasionally, doses up to 320 mg a day may be needed.
[Antianxiety therapy adjunct] -Oral, 10 to 80 mg thirty to ninety minutes prior to the anxiety-provoking activity.
[Thyrotoxicosis therapy adjunct] -Oral, 10 to 40 mg three or four times a day, the dosage being adjusted as needed and tolerated.
Note: Twice-daily or, in some patients, once-daily dosing may be effective for use as an antianginal, antihypertensive, or for myocardial infarction.
Geriatric patients may have increased or decreased sensitivity to the effects of the usual adult dose. |
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MAXIMUM ADULT DOSE:
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PEDIATRIC DOSE:
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Antiarrhythmic
Antihypertensive-Initial: Oral, 500 mcg (0.5 mg) to 1 mg per kg of body weight per day in two to four divided doses has been used as an initial dose, the dosage being adjusted as necessary to treat hypertension and prevent supraventricular tachycardia.
Maintenance: Oral, 2 to 4 mg per kg per day in two divided doses. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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