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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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SIDE EFFECTS:
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Anemia, megaloblastic |
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hypoglycemia |
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lactic acidosis |
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Anorexia |
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diarrhea |
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dyspepsia |
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flatulence |
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headache |
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metallic taste |
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nausea |
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vomiting |
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weight loss |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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>> Intestinal obstruction |
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>> Vomiting |
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>> Other conditions causing delayed food absorption |
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>> Hyperglycemia-causing conditions |
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Female hormonal changes |
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Fever, high |
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Hypercortisolism, not optimally treated |
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Psychological stress |
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>> Hyperthyroidism, not optimally controlled |
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>> Hypoglycemia-causing conditions |
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Adrenal insufficiency, not optimally controlled |
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Debilitated physical condition |
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Malnutrition |
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Pituitary insufficiency, not optimally controlled |
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>> Hypothyroidism, not optimally controlled |
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>> Diarrhea |
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>> Gastroparesis |
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ADULT DOSE:
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Antihyperglycemic agent-
As monotherapy-
Initial-Oral, 500 mg two times a day, taken with morning and evening meals. The daily dose may be increased by 500 mg at weekly intervals as needed. An alternative dose is 850 mg a day, taken with the morning meal. The daily dose may be increased by 850 mg at fourteen-day intervals.
Maintenance-Oral, 500 or 850 mg two to three times a day, taken with meals.
In combination with a sulfonylurea-
The dosage of each agent must be adjusted until the desired degree of glycemic control is achieved.
In combination with insulin -
Oral, initially 500 mg a day. The dosage may be increased by 500 mg at weekly intervals as needed.
Note:
The current insulin dose should be continued upon initiation of metformin therapy. However, the insulin dose should be decreased by 10 to 25% when the fasting plasma glucose concentration decreases to less than 120 mg per dL (6.7 mmol per L). |
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MAXIMUM ADULT DOSE:
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2550 mg a day.
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PEDIATRIC DOSE:
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Safety and efficacy have not been established.
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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Antihyperglycemic agent-
As monotherapy-
Initial-Oral, 500 mg two times a day, taken with morning and evening meals. The daily dose may be increased by 500 mg at weekly intervals as needed. An alternative dose is 850 mg a day, taken with the morning meal. The daily dose may be increased by 850 mg at fourteen-day intervals.
Maintenance-Oral, 500 or 850 mg two to three times a day, taken with meals.
In combination with a sulfonylurea-
The dosage of each agent must be adjusted until the desired degree of glycemic control is achieved.
In combination with insulin -
Oral, initially 500 mg a day. The dosage may be increased by 500 mg at weekly intervals as needed.
Note:
The current insulin dose should be continued upon initiation of metformin therapy. However, the insulin dose should be decreased by 10 to 25% when the fasting plasma glucose concentration decreases to less than 120 mg per dL (6.7 mmol per L). |
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