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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Adenoma, multiple endocrine |
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Esophagitis, erosive |
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Gastroesophageal Reflux Disease |
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Mastocytosis, systemic |
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Ulcer, duodenal |
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Ulcer, gastric |
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Zollinger- Ellison syndrome |
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SIDE EFFECTS:
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gastrointestinal disturbances, specifically acid regurgitation |
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constipation |
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diarrhea or loose stools |
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flatulence |
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nausea and vomiting |
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skin rash or itching |
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Generalized skin reactions, including toxic epidermal necrolysis |
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Stevens-Johnson syndrome |
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erythema multiforme |
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hematologic abnormalities, specifically anemia |
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agranulocytosis |
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hemolytic anemia |
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leukocytosis |
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neutropenia |
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pancytopenia or thrombocytopenia |
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hematuria |
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proteinuria |
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urinary tract infection |
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Abdominal pain or colic |
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Asthenia |
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back pain |
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central nervous system (CNS) disturbances , specifically dizziness |
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headache |
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somnolence |
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unusual tiredness |
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chest pain |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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>> Hepatic disease, chronic, current |
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ADULT DOSE:
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Gastroesophageal reflux disease (treatment) -
Oral, 20 mg once a day for four to eight weeks.
Note: A dosage of 40 mg once a day has been used for esophagitis associated with gastroesophageal reflux disease refractory to other treatment regimens.
Erosive esophagitis (prophylaxis)-
Oral, 20 mg once a day.
Gastric hypersecretory conditions (e.g., Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas) -
Oral, 60 mg once a day, the dosage being adjusted as needed, and therapy continued for as long as clinically indicated. Doses of up to 120 mg three times a day have been used. If the total daily dose is greater than 80 mg, it should be administered in divided doses.
Duodenal ulcer-
Oral, 20 mg once a day.
Note: The dosage can be increased to 40 mg once a day for duodenal ulcer refractory to other treatment regimens.
Gastric ulcer (treatment)-
Oral, 40 mg once a day for four to eight weeks.
Peptic ulcer associated with Helicobacter pylori infection-
Oral, omeprazole 40 mg once a day before breakfast taken in combination with clarithromycin 500 mg three times a day for the first fourteen days .
For days 15 through 28, further treatment with omeprazole 20 mg once a day before breakfast follows . |
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MAXIMUM ADULT DOSE:
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PEDIATRIC DOSE:
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Safety and efficacy have not been established.
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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