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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Anxiety disorder, generalized |
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Depression |
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SIDE EFFECTS:
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palpitation |
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tachycardia |
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CNS effects |
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abnormal thinking |
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agitation |
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confusion |
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depersonalization |
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emotional lability |
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tinnitus |
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Dyspnea |
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edema |
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itching or skin rash |
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mania or hypomania |
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menstrual changes |
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orthostatic hypotension |
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seizures |
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trismus |
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urinary effects, including impaired urination |
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urinary frequency |
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urinary incontinence |
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urinary retention |
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Abnormal dreams |
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anorexia |
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anxiety or nervousness |
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asthenia |
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chills |
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constipation |
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diarrhea |
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dizziness |
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dryness of mouth |
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dyspepsia |
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increased sweating |
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insomnia |
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nausea |
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paresthesia |
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rhinitis |
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somnolence |
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stomach pain or gas |
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tremor |
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vomiting |
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weight loss |
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yawning |
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Hypertonia |
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taste perversion |
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Asthenia |
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changes in dreaming |
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dizziness |
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dryness of mouth |
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headache |
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increased sweating |
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insomnia |
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nausea |
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Headache |
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hypertension |
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sexual dysfunction, including anorgasmia |
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decreased libido |
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delayed ejaculation |
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impotence |
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vision disturbances, including abnormal accommodation |
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blurred vision |
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Cardiovascular effects, other, including chest pain |
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nervousness |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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>> Blood pressure problems |
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>> Cardiac disease |
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>> Hepatic function impairment |
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>> Mania |
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Neurological impairment, including mental retardation |
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>> Renal function impairment |
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Seizures |
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Sensitivity to venlafaxine |
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Weight loss |
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ADULT DOSE:
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Antidepressant-
Oral, initially 75 mg a day , administered in two or three divided doses and taken with food .
The dosage may be increased, as needed and tolerated, in increments up to 75 mg a day at intervals of no less than four days , up to 225 mg a day .
Although dosages over 225 mg a day have not been shown to be useful in moderately depressed outpatients, more severely depressed patients may respond to dosages of up to 375 mg a day, administered in three divided doses .
Note: Some clinicians recommend an initial dosage of 50 mg a day administered in two divided doses in the treatment of mild depression in order to minimize nausea .
In patients with moderate to severe hepatic function impairment- Dosage reductions of 50% or more are recommended .
In patients with renal function impairment- Mild to moderate: Dosage reductions of 25% are recommended .
Moderate to severe (CL < 30 mL/min): Dosage should be reduced by 50% .
The dose may be administered once a day because of the prolonged half-life .
In dialysis patients: Total daily dose should be reduced by 50%, and administration withheld until dialysis treatment is completed . |
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MAXIMUM ADULT DOSE:
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375 mg a day .
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PEDIATRIC DOSE:
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Safety and efficacy in children up to 18 years of age have not been established .
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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Antidepressant-
Oral, initially 75 mg a day , administered in two or three divided doses and taken with food .
The dosage may be increased, as needed and tolerated, in increments up to 75 mg a day at intervals of no less than four days , up to 225 mg a day .
Although dosages over 225 mg a day have not been shown to be useful in moderately depressed outpatients, more severely depressed patients may respond to dosages of up to 375 mg a day, administered in three divided doses .
Note: Some clinicians recommend an initial dosage of 50 mg a day administered in two divided doses in the treatment of mild depression in order to minimize nausea .
In patients with moderate to severe hepatic function impairment- Dosage reductions of 50% or more are recommended .
In patients with renal function impairment- Mild to moderate: Dosage reductions of 25% are recommended .
Moderate to severe (CL < 30 mL/min): Dosage should be reduced by 50% .
The dose may be administered once a day because of the prolonged half-life .
In dialysis patients: Total daily dose should be reduced by 50%, and administration withheld until dialysis treatment is completed . |
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