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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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D
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INDICATIONS:
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Seizures, absence |
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Seizures, complex partial |
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SIDE EFFECTS:
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nausea and vomiting |
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trembling of hands and arms |
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unusual weight loss or gain |
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Ataxia |
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constipation |
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dizziness |
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drowsiness |
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headache |
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skin rash |
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unusual excitement, restlessness, or irritability |
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Behavioral, mood, or mental changes |
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hepatotoxicity or hyperammonemia |
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ophthalmological effects, specifically diplopia |
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nystagmus |
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spots before eyes |
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pancreatitis |
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platelet aggregation inhibition or thrombocytopenia |
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Abdominal or stomach cramps, mild |
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anorexia |
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change in menstrual periods |
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diarrhea |
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hair loss |
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indigestion |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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Blood dyscrasias |
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Brain disease, |
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Hepatic disease |
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Hypoalbuminemia |
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Renal function impairment |
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ADULT DOSE:
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Anticonvulsant-
Monotherapy: Oral, initially, 5 to 15 mg per kg of body weight a day, the dosage being increased at one-week intervals by 5 to 10 mg per kg of body weight a day as needed and tolerated.
Polytherapy: Oral, initially, 10 to 30 mg per kg of body weight a day, the dosage being increased at one-week intervals by 5 to 10 mg per kg of body weight a day as needed and tolerated.
Note: If the total daily dose exceeds 250 mg, it should be divided into two or more doses (usually given every 12 hours ) to lessen the possibility of gastrointestinal irritation.
Geriatric patients may need lower doses.
Patients also taking a hepatic enzyme-inducing medication may need higher dosages depending on predose serum concentrations. |
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MAXIMUM ADULT DOSE:
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60 mg per kg of body weight a day.
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PEDIATRIC DOSE:
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Anticonvulsant-Children 1 to 12 years of age-
Monotherapy: Oral, initially, 15 to 45 mg per kg of body weight a day, the dosage being increased at one-week intervals by 5 to 10 mg per kg of body weight a day as needed and tolerated.
Polytherapy: Oral, 30 to 100 mg per kg of body weight a day.
Note: Dosage adjustments depend on clinical response and serum anticonvulsant concentrations. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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Geriatric patients may need lower doses .
See Usual adult and adolescent dose .
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