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SIZE:
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GENERIC NAME:
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MANUFACTURER:
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UNIT:
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ADMINISTRATION ROUTE:
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FDA PREGNANCY GROUP:
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C
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INDICATIONS:
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Anemia, megaloblastic |
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Carcinoma, colorectal, adjunct |
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Osteosarcoma |
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Toxicity, methotrexate |
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SIDE EFFECTS:
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Allergic reaction |
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seizures |
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ABSOLUTE
CONTRAINDICATIONS :
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RELATIVE
CONTRAINDICATIONS : |
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ADULT DOSE:
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Antidote (to folic acid antagonists)-
To methotrexate (inadvertent overdose)-
Intramuscular or intravenous, 10 mg (base) per square meter of body surface area every six hours until methotrexate blood concentrations fall to less than 5 ´ 10 Molar.
Note:
If, at 24 hours following methotrexate administration, the serum creatinine is increased by 50% or greater over baseline or serum methotrexate is greater than 5 ´ 10 Molar, the dose of leucovorin should be 100 mg (base) per square meter of body surface area every three hours intravenously until methotrexate concentrations are reduced to appropriate levels.
To pyrimethamine or trimethoprim-
Prevention-Intramuscular, 400 mcg (0.4 mg) to 5 mg (base) with each dose of the folic acid antagonist.
Treatment-Intramuscular, 5 to 15 mg (base) per day.
Megaloblastic anemia, secondary to folate deficiency-
Intramuscular, up to 1 mg (base) per day.
Note: Because of its calcium content, leucovorin calcium injection should be administered by intravenous injection slowly, at a rate that does not exceed 160 mg of leucovorin per minute. |
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MAXIMUM ADULT DOSE:
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PEDIATRIC DOSE:
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Antidote (to folic acid antagonists)-
To methotrexate (inadvertent overdose)-
Intramuscular or intravenous, 10 mg (base) per square meter of body surface area every six hours until methotrexate blood concentrations fall to less than 5 ´ 10 Molar.
Note:
If, at 24 hours following methotrexate administration, the serum creatinine is increased by 50% or greater over baseline or serum methotrexate is greater than 5 ´ 10 Molar, the dose of leucovorin should be 100 mg (base) per square meter of body surface area every three hours intravenously until methotrexate concentrations are reduced to appropriate levels.
To pyrimethamine or trimethoprim-
Prevention-Intramuscular, 400 mcg (0.4 mg) to 5 mg (base) with each dose of the folic acid antagonist.
Treatment-Intramuscular, 5 to 15 mg (base) per day.
Megaloblastic anemia, secondary to folate deficiency-
Intramuscular, up to 1 mg (base) per day.
Note: Because of its calcium content, leucovorin calcium injection should be administered by intravenous injection slowly, at a rate that does not exceed 160 mg of leucovorin per minute. |
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MAXIMUM PEDIATRIC
DOSE:
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ELDERLY DOSE:
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