ARGININE INTRAVENOUS INFUSION



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SIZE :
 
INDICATIONS :
 
  • angina†
 
  • cystitis†
 
  • erectile dysfunction (ED)†
 
  • hypochloremia
 
  • metabolic alkalosis
 
ABSOLUTE CONTRAINDICATIONS :
 
RELATIVE CONTRAINDICATIONS :
 
SIDE EFFECTS :
 

 

 
ADULT DOSE
 
For evaluation of pituitary growth hormone reserve in patients with known or suspected growth hormone deficiency:Intravenous dosage:Adults: 300 ml IV over 30 minutes.Children: 500 mg/kg IV over 30 minutes.For the management of severe, uncompensated, metabolic alkalosis (pH >= 7.55) after optimizing therapy with sodium, potassium, ammonium chloride supplements:Intravenous dosage:Adults and children: The dose may be obtained by using the following formula: Arginine dose (g) = weight (kg) x 0.1 x [HCO3° - 24] where HCO3° is equal to the patient's serum bicarbonate concentration in mEq/L; give one-half to two-thirds of the calculated dose and re-evaluate. If pituitary function is normal, human growth hormone levels should rise after arginine administration to 10-30 ng/ml (control range: 0-6 ng/ml).For the adjunctive treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle†:•for patients with carbamyl phosphate synthetase or ornithine transcarbamylase deficiency: Intravenous infusion dosage:Adults, adolescents, children, infants, and neonates: 200 mg/kg IV over 90-120 minutes, then 200 mg/kg IV over 24 hours with each sodium benzoate; sodium phenylacetate maintenance infusion dose.•for patients with argininosuccinate lyase or argininosuccinate synthetase deficiency:Intravenous infusion dosage:Adults, adolescents, children, infants, and neonates: 600 mg/kg IV over 90-120 minutes, then 600 mg/kg IV over 24 hours with each sodium benzoate; sodium phenylacetate maintenance infusion dose.
MAXIMUM ADULT DOSE:
 
PEDIATRIC DOSE :
 
To correct hypochloremia:Intravenous dosage:children: The dose may be obtained by using the following formula: Arginine dose (ml) = weight (kg) x 0.4 x [103 - Cl°] where Cl° is equal to the patient's serum chloride concentration in mEq/L; give one-half to two-thirds of the calculated dose and re-evaluate.
MAXIMUM PEDIATRIC DOSE:
 
GERIATRIC DOSE:
 
PREGNANCY GROUP