Actinomycin D

Gestational Trophoblastic Neoplasia

Adult Dose:

0.01 mg/kg IV qd for 5 d as part of MAC regimen or as single agent (not to exceed 0.5 mg); repeat 14-16 d after last dose Alternatively, 0.5 mg IV on days 1 and 2 in EMA-CO regimen

Pediatric Dose:

<6 months: Not recommended >6 months: Administer as in adults

Granulosa-Theca Cell Tumors

Adult Dose:

15 mcg/kg/d IV q3-4wk or 0.5 mg/d on days 1-5 q3-4wk

Pediatric Dose:

Administer as in adults

Ovarian Dysgerminomas

Adult Dose:

VAC protocol: 0.5 mg IV over 5 d q4wk

Pediatric Dose:

Not established